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Blood, 1 January 2005, Vol. 105, No. 1, pp. 241-250. Prepublished online as a Blood First Edition Paper on September 2, 2004; DOI 10.1182/blood-2004-06-2482. This Article Full Text (PDF) All Versions of this Article: 2004-06-2482v1 105/1/241    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Powell Jr., D. J Articles by Rosenberg, S. A Search for Related Content PubMed PubMed Citation Articles by Powell Jr., D. J Articles by Rosenberg, S. A Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 30, 2004 Accepted August 4, 2004 Transition of late stage effector T cells to CD27+ CD28+ tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy Daniel J Powell Jr., Mark E Dudley, Paul F Robbins, and Steven A Rosenberg* Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA * Corresponding author; email: sar{at}nih.gov. In humans, the pathways of memory T-cell differentiation remain poorly defined. Recently, adoptive cell transfer (ACT) of tumor-reactive T lymphocytes to metastatic melanoma patients after non-myeloablative chemotherapy has resulted in persistence of functional, tumor-reactive lymphocytes, regression of disease, and induction of melanocyte-directed autoimmunity in some responding patients. In the current study, longitudinal phenotypic analysis was performed on melanoma antigen-specific CD8+ T-cells during their transition from in vitro cultured effector cells to long-term persistent memory cells following ACT to six responding patients. Tumor-reactive T-cells used for therapy were generally late stage effector cells with a CD27Lo CD28Lo CD45RA- CD62L- CCR7- IL-7RLo phenotype. After transfer, rapid upregulation and continued expression of IL-7R in vivo suggested an important role for IL-7R in immediate and long-term T-cell survival. Although the tumor antigen-specific T-cell population contracted between one and four weeks post-transfer, stable numbers of CD27+ CD28+ tumor-reactive T-cells were maintained, demonstrating their contribution to the development of long-term, melanoma-reactive memory CD8+ T-cells in vivo. Two months after transfer, melanoma-reactive T-cells persisted at high levels and displayed an effector memory phenotype, including a CD27+ CD28+ CD62L- CCR7- profile, which may explain in part their ability to mediate tumor destruction. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Long live T cells Laurence J. N. Cooper Blood 2005 105: 8-9. [Full Text] [PDF] This article has been cited by other articles: C. Brignone, B. Escudier, C. Grygar, M. Marcu, and F. Triebel A Phase I Pharmacokinetic and Biological Correlative Study of IMP321, a Novel MHC Class II Agonist, in Patients with Advanced Renal Cell Carcinoma Clin. Cancer Res., October 1, 2009; 15(19): 6225 - 6231. [Abstract] [Full Text] [PDF] C. A. Klebanoff, Z. Yu, L. N. Hwang, D. C. Palmer, L. Gattinoni, and N. P. 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