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Blood, 15 February 2005, Vol. 105, No. 4, pp. 1614-1621. Prepublished online as a Blood First Edition Paper on October 26, 2004; DOI 10.1182/blood-2004-07-2507. This Article Full Text (PDF) All Versions of this Article: 2004-07-2507v1 105/4/1614    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Odendahl, M. Articles by Dorner, T. Search for Related Content PubMed PubMed Citation Articles by Odendahl, M. Articles by Dorner, T. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 1, 2004 Accepted October 12, 2004 Generation of migratory antigen-specific plasma blasts and mobilisation of resident plasma cells in a secondary immune response Marcus Odendahl, Henrik Mei, Bimba F Hoyer, Annett M Jacobi, Arne Hansen, Gwendolin Muehlinghaus, Claudia Berek, Falk Hiepe, Rudi Manz, Andreas Radbruch, and Thomas Dorner* Department of Medicine, Rheumatology and Clinical Immunology, Charite University Medicine, Humboldt University at Berlin, Berlin, Germany; German Arthritis Research Center, Berlin, Germany German Arthritis Research Center, Berlin, Germany Department of Medicine, Rheumatology and Clinical Immunology, Charite University Medicine, Humboldt University at Berlin, Berlin, Germany Institute of Transfusion Medicine, Coagulation Unit, Charite University Medicine, Berlin, Germany * Corresponding author; email: thomas.doerner{at}charite.de. Maintenance of protective humoral immunity depends on the generation and survival of antibody-secreting cells. The bone marrow provides niches for long-term survival of plasma cells generated in the course of systemic immune responses in secondary lymphoid organs. Here, we have analysed migratory human plasma blasts and plasma cells after secondary vaccination with tetanus toxin. On days 6 and 7 after immunization, CD19+/CD27high/intracellular IgGhigh/HLA-DRhigh/CD38high/CD20-/CD95+ tetanus toxin-specific antibody-secreting plasma blasts were released in large numbers from the secondary lymphoid organs into the blood. These cells show chemotactic responsiveness towards ligands for CXCR3 and CXCR4, probably guiding them into the bone marrow or inflamed tissue. At the same time, a population of CD19+/CD27high/intracellular IgGhigh/HLA-DRlow/CD38+/CD20-/CD95+ cells appeared in the blood in large numbers. These cells with the phenotype of long-lived plasma cells secreted antibodies of unknown specificity, not tetanus toxoid. The appearance of these plasma cells in the blood indicates successful competition for survival niches in the bone marrow between newly generated plasma blasts and resident plasma cells, as a fundamental mechanism for the establishment of humoral memory and its plasticity. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. L. Carpenter, R. Mick, A. J. Rech, G. L. Beatty, T. A. Colligon, M. R. Rosenfeld, D. E. Kaplan, K.-M. Chang, S. M. Domchek, P. A. Kanetsky, et al. Collapse of the CD27+ B-Cell Compartment Associated with Systemic Plasmacytosis in Patients with Advanced Melanoma and Other Cancers Clin. Cancer Res., July 1, 2009; 15(13): 4277 - 4287. [Abstract] [Full Text] [PDF] H. E. Mei, T. Yoshida, W. Sime, F. Hiepe, K. Thiele, R. A. Manz, A. Radbruch, and T. 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