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Blood, 1 February 2005, Vol. 105, No. 3, pp. 1348-1354. Prepublished online as a Blood First Edition Paper on September 28, 2004; DOI 10.1182/blood-2004-07-2528. This Article Full Text (PDF) All Versions of this Article: 2004-07-2528v1 105/3/1348    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sanders, J. E Articles by Appelbaum, F. R Search for Related Content PubMed PubMed Citation Articles by Sanders, J. E Articles by Appelbaum, F. R Related Collections Related Letter in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 7, 2004 Accepted September 19, 2004 Final adult height of patients who received a childhood hematopoietic cell transplant Jean E Sanders*, Katherine A Guthrie, Paul A Hoffmeister, Ann E Woolfrey, Paul A Carpenter, and Frederick R Appelbaum Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Biostatistics, University of Washington School of Public Health and Community Medicine, Seattle, WA, USA Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA * Corresponding author; email: jsanders{at}fhcrc.org. Growth impairment and growth hormone (GH) deficiency are complications following total body irradiation (TBI) and hematopoietic cell transplant (HCT). To determine GH therapy impact on growth, final height of 90 GH deficient children given fractionated TBI and HCT for malignancy was evaluated. The changes in height standard deviation (SD) from GH deficiency diagnosis to final height were compared between 42 who did and 48 who did not receive GH therapy. At HCT, GH treated patients were younger (P = 0.001), more likely to have received central nervous system irradiation (P = 0.007), and were shorter (P = 0.005) than patients who did not receive GH therapy. After HCT, GH deficiency was diagnosed at 1.5 (0.8-9.5) years for GH treated and 1.2 (0.9-8.8) years for non-treated patients. GH therapy was associated with significantly improved final height in children younger than 10 years at HCT (P = 0.0001), but GH therapy did not impact the growth of older children. Female children (P = 0.0001) and children diagnosed with AML, CML, or MDS (versus ALL or NHL, P = 0.02) also showed more rapid growth compared to their counterparts. These data demonstrate that GH therapy improves the final height of young children following fractionated TBI. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Letter in Blood Online: Final height after transplantation in childhood Boudewijn Bakker, Wilma Oostdijk, Jan M. Wit, and Jean E. Sanders Blood 2005 106: 2592-2593. [Full Text] [PDF] This article has been cited by other articles: E. A. Copelan Hematopoietic stem-cell transplantation. N. Engl. J. Med., April 27, 2006; 354(17): 1813 - 1826. [Full Text] [PDF] B. Bakker, W. Oostdijk, J. M. Wit, and J. E. Sanders Final height after transplantation in childhood Blood, October 1, 2005; 106(7): 2592 - 2593. [Full Text] [PDF] Minerva BMJ, February 5, 2005; 330(7486): 316 - 316. [Full Text] [PDF]

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