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Blood, 1 June 2005, Vol. 105, No. 11, pp. 4407-4415. Prepublished online as a Blood First Edition Paper on February 22, 2005; DOI 10.1182/blood-2004-07-2529. This Article Full Text (PDF) Supplemental Figures All Versions of this Article: 2004-07-2529v1 105/11/4407    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pelayo, R. Articles by Kincade, P. W Search for Related Content PubMed PubMed Citation Articles by Pelayo, R. Articles by Kincade, P. W Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 6, 2004 Accepted January 30, 2005 Derivation of two categories of plasmacytoid dendritic cells in murine bone marrow Rosana Pelayo, Jun Hirose, Jiaxue Huang, Karla P Garrett, Alessio Delogu, Meinrad Busslinger, and Paul W Kincade* Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA Research Institute of Molecular Pathology, Vienna, Austria * Corresponding author; email: kincade{at}omrf.ouhsc.edu. Plasmacytoid dendritic cells (pDC) competent to make type I interferon were rigorously defined as a Ly-6C+ and CD11clo subset of the B220+CD19-CD43+CD24lo bone marrow (BM) Fraction A. Otherwise similar Ly6C- cells expressed the NK markers DX5 and NK1.1. pDC represented a stable, discrete and long-lived population. Stem cells and early lymphoid progenitors (ELP), but not pro-lymphocytes were effective precursors of pDC and their differentiation was blocked by ligation of Notch receptors. Furthermore, pDC were present in the BM of RAG1-/-, IL-7R-/- and Pax5-/- mice. pDC in RAG1/GFP knock-in mice could be sub-divided, and immunoglobulin DH-JH rearrangements, as well as transcripts for the B lineage related genes Pax5, Ig Ig and Bcl11a were identified only in the GFP+ pDC1 subset. All pDC expressed TdT, Spi-B, RelB, TLR-9 and ICSBP/IRF-8 transcripts, lacked CD16 and G-CSFR and were uniformly IL-7R-, AA4.1Lo, CD27-, Flk-2Lo, c-Kit-, DX-5-, and CD11b-, while CD4 and CD8 were variable. GFP+ pDC1 subset was less potent than GFP- pDC2 in T allo-stimulation and production of TNF, IFN, and IL-6 while only pDC2 made IFNand IL-12 p70. Thus, two functionally specialized subsets of pDC arise in bone marrow from progenitors that diverge from B, T and NK lineages at an early stage. 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