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Blood, 1 December 2004, Vol. 104, No. 12, pp. 3672-3678. Prepublished online as a Blood First Edition Paper on August 12, 2004; DOI 10.1182/blood-2004-07-2540. This Article Full Text (PDF) All Versions of this Article: 2004-07-2540v1 104/12/3672    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Aandahl, E. M Articles by Sandberg, J. K Search for Related Content PubMed PubMed Citation Articles by Aandahl, E. M Articles by Sandberg, J. K Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 7, 2004 Accepted July 23, 2004 Expansion of CD7low and CD7negative CD8 T cell effector subsets in HIV-1 infection: correlation with antigenic load and reversion by antiretroviral treatment Einar M Aandahl, Maire F Quigley, Walter J Moretto, Markus Moll, Veronica D Gonzalez, Anders Sonnerborg, Stefan Lindback, Frederick M Hecht, Steven G Deeks, Michael G Rosenberg, Douglas F Nixon, and Johan K Sandberg* Biotechnology Center of Oslo, University of Oslo, Oslo, Norway Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, USA Division for Infectious Diseases, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden Department of Medicine, University of California San Francisco and San Francisco General Hospital, San Francisco, CA, USA Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA * Corresponding author; email: johan.sandberg{at}medhs.ki.se. The antiviral response of CD8 T cells involves the differentiation of naive T cells into distinct types of effector and memory cells, which may be distinguished by the level of CD7 expression. We have investigated CD8 T cells in HIV-1 infected adults and children to determine the disease relevance of cell subsets defined by CD7. CD8 T cells from HIV-1 infected patients displayed profound down-modulation of CD7 expression as compared to healthy subjects, with expansion of both CD7low and CD7negative effector subsets. Loss of CD7high cells correlated directly with HIV-1 load and was particularly pronounced in patients with rapid disease progression. CD8 T cells specific for HIV-1, as well as EBV and CMV, were predominantly found in the CD7low effector cell subset. Furthermore, recovery of CD4 counts on antiretroviral therapy was associated with reversion of the skewed CD7 profile in CD8 T cells. Thus, effector CD8 T cell subsets distinguished by lowered CD7 expression expand in a manner that correlates with the magnitude of HIV-1, EBV and CMV antigenic challenge, and contract in response to successful antiretroviral treatment. The results are discussed in relation to the dual roles of CD7 as a receptor of both co-stimulation and cell death. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: N. K. Bjorkstrom, V. D. Gonzalez, K.-J. Malmberg, K. Falconer, A. Alaeus, G. Nowak, C. Jorns, B.-G. Ericzon, O. Weiland, J. K. Sandberg, et al. Elevated Numbers of Fc{gamma}RIIIA+ (CD16+) Effector CD8 T Cells with NK Cell-Like Function in Chronic Hepatitis C Virus Infection J. Immunol., September 15, 2008; 181(6): 4219 - 4228. [Abstract] [Full Text] [PDF]

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