|
|
Blood, 1 February 2005, Vol. 105, No. 3, pp. 1362-1364.
Prepublished online as a Blood First Edition Paper on September 30, 2004; DOI 10.1182/blood-2004-07-2602.
 Previous Article | Next Article 
Submitted July 9, 2004
Accepted September 21, 2004
Cross-recognition of human alloantigen by cytomegalovirus glycoprotein-specific CD4+ cytotoxic T lymphocytes: implications for graft-versus-host disease
Rebecca Elkington and Rajiv Khanna*
Tumour Immunology Laboratory and Co-operative Centre for Vaccine Technology, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Joint Oncology Program, Department of Molecular and Cellular Pathology, University of Queensland, Brisbane, Queensland, Australia
* Corresponding author; email: rajivK{at}qimr.edu.au.
Presence of the HLA-DR7 allele in transplant patients has been proposed as a risk factor for human cytomegalovirus (HCMV)-associated complications, however, the precise mechanism of this increased risk remains unresolved. Here we show that HLA-DR7-restricted HCMV-specific CD4+ CTLs can display an unusual dual specificity towards a gylcoprotein-B epitope and the alloantigen HLA-DR4. On the other hand, no HLA-DR4-specific alloreactivity was observed when the gB-specific CTLs were generated from virus carriers expressing both HLA-DR7 and DR4 alleles. This most likely demonstrates the clonal inactivation of potentially self-reactive T cells in humans. Fine specificity analysis showed that gB-specific CTLs from HLA-DR7+/DR4- individuals displayed a distinct pattern of recognition when compared to CTLs from HLA-DR7+/DR4+ individuals, presumably evading an area that mimics a structure presented on HLA-DR4. These data illustrate a possible mechanism for the clinical association between HCMV and graft-versus-host disease.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. Rist, C. Smith, M. J. Bell, S. R. Burrows, and R. Khanna
Cross-recognition of HLA DR4 alloantigen by virus-specific CD8+ T cells: a new paradigm for self-/nonself-recognition
Blood,
September 10, 2009;
114(11):
2244 - 2253.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Matthews, Z. Lim, B. Afzali, L. Pearce, A. Abdallah, S. Kordasti, A. Pagliuca, G. Lombardi, J. A. Madrigal, G. J. Mufti, et al.
Imbalance of effector and regulatory CD4 T cells is associated with graft-versus-host disease after hematopoietic stem cell transplantation using a reduced intensity conditioning regimen and alemtuzumab
Haematologica,
July 1, 2009;
94(7):
956 - 966.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Stapler, E. D. Lee, S. A. Selvaraj, A. G. Evans, L. S. Kean, S. H. Speck, C. P. Larsen, and S. Gangappa
Expansion of Effector Memory TCR V{beta}4+CD8+ T Cells Is Associated with Latent Infection-Mediated Resistance to Transplantation Tolerance
J. Immunol.,
March 1, 2008;
180(5):
3190 - 3200.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Delmas, P. Brousset, D. Clement, E. Le Roy, and J.-L. Davignon
Anti-IE1 CD4+ T-cell clones kill peptide-pulsed, but not human cytomegalovirus-infected, target cells
J. Gen. Virol.,
September 1, 2007;
88(9):
2441 - 2449.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Tu, L. Potena, P. Stepick-Biek, L. Liu, K. Y. Dionis, H. Luikart, W. F. Fearon, T. H. Holmes, C. Chin, J. P. Cooke, et al.
T-Cell Immunity to Subclinical Cytomegalovirus Infection Reduces Cardiac Allograft Disease
Circulation,
October 10, 2006;
114(15):
1608 - 1615.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
