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Blood, 1 April 2005, Vol. 105, No. 7, pp. 2988-2990. Prepublished online as a Blood First Edition Paper on December 2, 2004; DOI 10.1182/blood-2004-07-2646. This Article Full Text (PDF) All Versions of this Article: 2004-07-2646v1 105/7/2988    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Wagner, A.-M. Articles by Krenger, W. Search for Related Content PubMed PubMed Citation Articles by Wagner, A.-M. Articles by Krenger, W. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 14, 2004 Accepted November 23, 2004 Leydig cell injury as a consequence of an acute graft-versus-host reaction Anna-Margaretha Wagner, Konstantin Beier, Elli Christen, Georg A Hollander, and Werner Krenger* Departments of Research and Clinical-Biological Sciences, Center for Biomedicine, University of Basel, and University Children's Hospital of both Basel (UKBB), Basel, Switzerland Institute of Anatomy, University of Basel, Basel, Switzerland * Corresponding author; email: werner.krenger{at}unibas.ch. Hematopoietic stem cell transplantation (HSCT) is associated with significant posttransplant gonadotoxicity. This deficit has been mainly attributed to pretransplant conditioning but lower sperm counts in humans also appear to be associated with graft-versus-host disease (GVHD) following allogeneic HSCT. However, the mechanisms leading to diminished spermatocyte levels during GVHD remain unknown. Here we demonstrate that injury to intratesticular cells occurs in unconditioned F1 mice following the infiltration of donor alloreactive T-cells during an acute graft-versus-host reaction (GVHR). Using computer-aided quantitative microscopic morphometry we demonstrate that the nadir of Leydig cell volume density coincides with the peak of intratesticular infiltration by donor T-cells. Injury to Leydig cells correlates with an intratesticular inflammatory response characterized by interferon-and tumor necrosis factor- production. These results demonstrate impairment of testosterone-producing Leydig cells during a local alloresponse, thus representing a mechanism that contributes to gonadal insufficiency following allogeneic HSCT. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. N. Savani, E. Kozanas, A. Shenoy, A. J. Barrett, A. Rovo, A. Tichelli, A. Gratwohl, and C. De Geyter Recovery of spermatogenesis after total-body irradiation Blood, December 15, 2006; 108(13): 4292 - 4294. [Full Text] [PDF] A. Rovo, A. Tichelli, J. R. Passweg, D. Heim, S. Meyer-Monard, W. Holzgreve, A. Gratwohl, and C. De Geyter Spermatogenesis in long-term survivors after allogeneic hematopoietic stem cell transplantation is associated with age, time interval since transplantation, and apparently absence of chronic GvHD Blood, August 1, 2006; 108(3): 1100 - 1105. [Abstract] [Full Text] [PDF]

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