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Blood, 1 May 2005, Vol. 105, No. 9, pp. 3535-3537. Prepublished online as a Blood First Edition Paper on December 2, 2004; DOI 10.1182/blood-2004-07-2676. This Article Full Text (PDF) All Versions of this Article: 2004-07-2676v1 105/9/3535    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by BitMansour, A. Articles by Brown, J. M Y Search for Related Content PubMed PubMed Citation Articles by BitMansour, A. Articles by Brown, J. M Y Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 14, 2004 Accepted September 30, 2004 Single infusion of myeloid progenitors reduces death from Aspergillus fumigatus following chemotherapy-induced neutropenia Andrew BitMansour, Thai M Cao, Stephanie Chao, Sumana Shashidhar, and Janice M Y Brown* Department of Medicine, Stanford University, Stanford, CA, USA * Corresponding author; email: wesbrown{at}stanford.edu. Hematopoietic progenitors committed to the myeloid lineage, the common myeloid and granulocyte-monocyte progenitors (CMP/GMP) have been shown to protect against opportunistic pathogens following myeloablative radiation; however, the efficacy of this approach has not been studied in the setting of chemotherapy-induced neutropenia. In this mouse model, the infusion of CMP/GMP on the day after 5-fluorouracil (5-FU) administration (D+1) resulted in a significant increase in the number of splenic neutrophils by D+8 when compared to 5-FU only controls (P=0.02), the majority of which were CMP/GMP-derived (54%). Moreover, 19% and 28% of neutrophils in the blood and bone marrow, respectively, were CMP/GMP-derived. Survival following intranasal challenge with the fungus Aspergillus fumigatus was significantly higher in CMP/GMP-infused mice than the controls (56% and 33% respectively; P=0.019). Thus, a single infusion of CMP/GMP enhances tissue neutrophil content and increases survival against a lethal challenge with A. fumigatus in the setting of chemotherapy-induced neutropenia. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. R. Hood, D. Burton, J. M. Wilkinson, and H. M. A. Cavanagh Antifungal activity of Leptospermum petersonii oil volatiles against Aspergillus spp. in vitro and in vivo J. Antimicrob. Chemother., December 1, 2009; (2009) dkp400v1. [Abstract] [Full Text] [PDF]

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