SEARCH:   Advanced

Blood, 1 June 2005, Vol. 105, No. 11, pp. 4523-4526. Prepublished online as a Blood First Edition Paper on February 10, 2005; DOI 10.1182/blood-2004-07-2762. This Article Full Text (PDF) All Versions of this Article: 2004-07-2762v1 105/11/4523    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chan, E. M Articles by Hromas, R. A Search for Related Content PubMed PubMed Citation Articles by Chan, E. M Articles by Hromas, R. A Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 19, 2004 Accepted January 21, 2005 AML1-FOG2 Fusion Protein in Myelodysplasia Edward M Chan*, Elisha M Comer, Frank C Brown, Kathleen E Richkind, Melissa L Holmes, Beng H Chong, Roger Shiffman, Dong-Er Zhang, Marilyn L Slovak, Cheryl L Willman, Constance T Noguchi, Yanjun Li, Devan J Heiber, Lori Kwan, Rebecca J Chan, Gail H Vance, Heather C Ramsey, and Robert A Hromas Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana University Cancer Center, Indianapolis, IN, USA Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA Genzyme Genetics, Santa Fe, NM, USA Department of Medicine, University of New South Wales, Sydney, NSW, Australia Monterey Bay Oncology Center, Monterey, CA, USA Scripps Research Institute, La Jolla, CA, USA City of Hope National Medical Center, Duarte, CA, USA Department of Pathology, University of New Mexico, Albuquerque, NM, USA; Department of Medicine, University of New Mexico, Albuquerque, NM, USA; Department of Cancer Research & Treatment Center, University of New Mexico, Albuquerque, NM, USA National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianaplis, IN, USA Department of Medicine, University of New Mexico, Albuquerque, NM, USA Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianaplis, IN, USA; Indiana University Cancer Center, Indianapolis, IN, USA Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianaplis, IN, USA; Indiana University Cancer Center, Indianapolis, IN, USA Department of Medicine, University of New Mexico, Albuquerque, NM, USA; Department of Cancer Research & Treatment Center, University of New Mexico, Albuquerque, NM, USA * Corresponding author; email: echan{at}iupui.edu. Core binding factor (CBF) participates in specification of the hematopoietic stem cell and functions as a critical regulator of hematopoiesis. Translocation or point mutation of AML1/RUNX1, which encodes the DNA-binding subunit of CBF, plays a central role in the pathogenesis of acute myeloid leukemia and myelodysplasia. We characterized the translocation t(X;21)(p22.3;q22.1) in a patient with myelodysplasia that fuses AML1 in-frame to the novel partner gene Friend of GATA-2 (FOG2/ZFPM2). The reciprocal gene fusions AML1-FOG2 and FOG2-AML1 are both expressed. AML1-FOG2, which fuses the DNA-binding domain of AML1 to most of FOG2, represses the transcriptional activity of both CBF and GATA1. AML1-FOG2 retains a motif that recruits the corepressor CtBP and these proteins associate in a protein complex. These results suggest a central role for CtBP in AML1-FOG2 transcriptional repression and implicate coordinated disruption of the AML1 and GATA developmental programs in the pathogenesis of myelodysplasia. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. W. O'Malley and R. Kumar Nuclear Receptor Coregulators in Cancer Biology Cancer Res., November 1, 2009; 69(21): 8217 - 8222. [Abstract] [Full Text] [PDF] Z. Yang, T. Kondo, C. S. Voorhorst, S. C. Nabinger, L. Ndong, F. Yin, E. M. Chan, M. Yu, O. Wurstlin, C. P. Kratz, et al. Increased c-Jun Expression and Reduced GATA2 Expression Promote Aberrant Monocytic Differentiation Induced by Activating PTPN11 Mutants Mol. Cell. Biol., August 15, 2009; 29(16): 4376 - 4393. [Abstract] [Full Text] [PDF] E. DE BRAEKELEER, C. FEREC, and M. DE BRAEKELEER RUNX1 Translocations in Malignant Hemopathies Anticancer Res, April 1, 2009; 29(4): 1031 - 1037. [Abstract] [Full Text] [PDF] L. F. Peterson, M. Yan, and D.-E. Zhang The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO Blood, May 15, 2007; 109(10): 4392 - 4398. [Abstract] [Full Text] [PDF] N. Asou, M. Yanagida, L. Huang, M. Yamamoto, K. Shigesada, H. Mitsuya, Y. Ito, and M. Osato Concurrent transcriptional deregulation of AML1/RUNX1 and GATA factors by the AML1-TRPS1 chimeric gene in t(8;21)(q24;q22) acute myeloid leukemia Blood, May 1, 2007; 109(9): 4023 - 4027. [Abstract] [Full Text] [PDF]

	Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020