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Blood, 15 March 2005, Vol. 105, No. 6, pp. 2421-2427. Prepublished online as a Blood First Edition Paper on September 21, 2004; DOI 10.1182/blood-2004-07-2823. This Article Full Text (PDF) All Versions of this Article: 2004-07-2823v1 105/6/2421    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Piccio, L. Articles by Colonna, M. Search for Related Content PubMed PubMed Citation Articles by Piccio, L. Articles by Colonna, M. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 21, 2004 Accepted September 14, 2004 Adhesion of human T cells to antigen-presenting cells through SIRP2-CD47 interaction costimulates T cell proliferation Laura Piccio, Wiliam Vermi, Kent S Boles, Anja Fuchs, Carey A Strader, Fabio Facchetti, Marina Cella, and Marco Colonna* Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA; Department of Neurological Sciences, IRCCS Ospedale Maggiore Policlinico, and 'Dino Ferrari' Center, Milano, Italy Department of Pathology, University of Brescia, Brescia, Italy Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA * Corresponding author; email: mcolonna{at}pathology.wustl.edu. Signal-regulatory proteins (SIRPs) are transmembrane glycoproteins belonging to the immunoglobulin (Ig) superfamily that are expressed in the immune and central nervous system. SIRP binds CD47 and inhibits the function of macrophages, dendritic cells and granulocytes, whereas SIRP1 is an orphan receptor that activates the same cell types. A recently identified third member of the SIRP family, SIRP2, is as yet uncharacterized in terms of expression, specificity and function. Here we show that SIRP2 is expressed on T cells and activated natural killer (NK) cells and, like SIRP, binds CD47, mediating cell-cell adhesion. Consequently, engagement of SIRP2 on T cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T cell proliferation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: CD47 and SIRPs: new openings Per-Arne Oldenborg Blood 2005 105: 2245-2246. [Full Text] [PDF] This article has been cited by other articles: A. Junker, M. Krumbholz, S. Eisele, H. Mohan, F. Augstein, R. Bittner, H. Lassmann, H. Wekerle, R. Hohlfeld, and E. Meinl Micro-ribonucleic acid profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47 Brain, December 1, 2009; (2009) awp300v1. [Abstract] [Full Text] [PDF] F. Guimont-Desrochers, C. Beauchamp, G. Chabot-Roy, V. Dugas, E. E. Hillhouse, J. Dusseault, G. Langlois, P. Gautier-Ethier, J. Darwiche, M. Sarfati, et al. Absence of CD47 in vivo influences thymic dendritic cell subset proportions but not negative selection of thymocytes Int. Immunol., February 1, 2009; 21(2): 167 - 177. [Abstract] [Full Text] [PDF] J. S. Isenberg, D. S. Annis, M. L. Pendrak, M. Ptaszynska, W. A. Frazier, D. F. Mosher, and D. D. Roberts Differential Interactions of Thrombospondin-1, -2, and -4 with CD47 and Effects on cGMP Signaling and Ischemic Injury Responses J. Biol. Chem., January 9, 2009; 284(2): 1116 - 1125. [Abstract] [Full Text] [PDF] H. Umemori and J. R. Sanes Signal Regulatory Proteins (SIRPS) Are Secreted Presynaptic Organizing Molecules J. Biol. Chem., December 5, 2008; 283(49): 34053 - 34061. [Abstract] [Full Text] [PDF] M. Stefanidakis, G. Newton, W. Y. Lee, C. A. Parkos, and F. W. Luscinskas Endothelial CD47 interaction with SIRP{gamma} is required for human T-cell transendothelial migration under shear flow conditions in vitro Blood, August 15, 2008; 112(4): 1280 - 1289. [Abstract] [Full Text] [PDF] L. Shi, K. Luo, D. Xia, T. Chen, G. Chen, Y. Jiang, N. Li, and X. Cao DIgR2, dendritic cell-derived immunoglobulin receptor 2, is one representative of a family of IgSF inhibitory receptors and mediates negative regulation of dendritic cell-initiated antigen-specific T-cell responses Blood, October 15, 2006; 108(8): 2678 - 2686. [Abstract] [Full Text] [PDF]

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