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Blood, 1 July 2005, Vol. 106, No. 1, pp. 18-26. Prepublished online as a Blood First Edition Paper on March 17, 2005; DOI 10.1182/blood-2004-08-2996. This Article Full Text (PDF) All Versions of this Article: 2004-08-2996v1 106/1/18    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Varona, R. Articles by Marquez, G. Search for Related Content PubMed PubMed Citation Articles by Varona, R. Articles by Marquez, G. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 3, 2004 Accepted March 9, 2005 CCR6 regulates CD4+ T-cell-mediated acute graft-versus-host disease responses Rosa Varona, Vanesa Cadenas, Lucio Gomez, Carlos Martinez-A, and Gabriel Marquez* Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia/CSIC, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain * Corresponding author; email: gmarquez{at}cnb.uam.es. We studied the role of chemokine receptor CCR6 in acute graft-versus-host disease (GvHD), a pathology in which activated, host antigen-specific donor T cells selectively damage tissues such as skin, liver and gut. GvHD incidence was reduced in MHC class II-mismatched recipients of CD4+ T cells from CCR6-deficient donors. In MHC-matched/minor histocompatibility antigen-mismatched recipients of CD4+CD45RBhigh T cells from CCR6-deficient donors, infiltration of CD45+ and CD4+ cells to skin and gut, as well as lesion onset, were significantly delayed, and pathological symptoms were milder. Consistent with this, in skin and gut of recipients of naive T cells from CCR6-deficient donors, we observed lower levels of IFN-, IL-10, and of the chemokines that control activated T-cell homing. We suggest a role for CCR6 in recruiting alloreactive CD4+ T cells to target tissues, and identify CCR6 as a potential therapeutic target for GvHD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. Socie and B. R. Blazar Acute graft-versus-host disease: from the bench to the bedside Blood, November 12, 2009; 114(20): 4327 - 4336. [Abstract] [Full Text] [PDF] N. Li, Y. Chen, W. He, T. Yi, D. Zhao, C. Zhang, C.-L. Lin, I. Todorov, F. Kandeel, S. Forman, et al. Anti-CD3 preconditioning separates GVL from GVHD via modulating host dendritic cell and donor T-cell migration in recipients conditioned with TBI Blood, January 22, 2009; 113(4): 953 - 962. [Abstract] [Full Text] [PDF] S. He, Q. Cao, Y. Qiu, J. Mi, J. Z. Zhang, M. Jin, H. Ge, S. G. Emerson, Y. Zhang, and Y. Zhang A New Approach to the Blocking of Alloreactive T Cell-Mediated Graft-versus-Host Disease by In Vivo Administration of Anti-CXCR3 Neutralizing Antibody J. Immunol., December 1, 2008; 181(11): 7581 - 7592. [Abstract] [Full Text] [PDF] S. P. Singh, H. H. Zhang, J. F. Foley, M. N. Hedrick, and J. M. Farber Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR6 J. Immunol., January 1, 2008; 180(1): 214 - 221. [Abstract] [Full Text] [PDF] M. Facco, I. Baesso, M. Miorin, M. Bortoli, A. Cabrelle, E. Boscaro, C. Gurrieri, L. Trentin, R. Zambello, F. Calabrese, et al. Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis J. Leukoc. Biol., October 1, 2007; 82(4): 946 - 955. [Abstract] [Full Text] [PDF] A. P. Phadke, G. Akangire, S. J. Park, S. A. Lira, and B. Mehrad The Role of CC Chemokine Receptor 6 in Host Defense in a Model of Invasive Pulmonary Aspergillosis Am. J. Respir. Crit. Care Med., June 1, 2007; 175(11): 1165 - 1172. [Abstract] [Full Text] [PDF] J. Chen, F. M. Ellison, M. A. Eckhaus, A. L. Smith, K. Keyvanfar, R. T. Calado, and N. S. Young Minor Antigen H60-Mediated Aplastic Anemia Is Ameliorated by Immunosuppression and the Infusion of Regulatory T Cells J. Immunol., April 1, 2007; 178(7): 4159 - 4168. [Abstract] [Full Text] [PDF] C. Zhang, J. Lou, N. Li, I. Todorov, C.-L. Lin, Y.-A. Cao, C. H. Contag, F. Kandeel, S. Forman, and D. Zeng Donor CD8+ T Cells Mediate Graft-versus-Leukemia Activity without Clinical Signs of Graft-versus-Host Disease in Recipients Conditioned with Anti-CD3 Monoclonal Antibody J. Immunol., January 15, 2007; 178(2): 838 - 850. [Abstract] [Full Text] [PDF] P. Ghadjar, S. E. Coupland, I.-K. Na, M. Noutsias, A. Letsch, A. Stroux, S. Bauer, H. J. Buhr, E. Thiel, C. Scheibenbogen, et al. Chemokine Receptor CCR6 Expression Level and Liver Metastases in Colorectal Cancer J. Clin. Oncol., April 20, 2006; 24(12): 1910 - 1916. [Abstract] [Full Text] [PDF] T. H. Terwey, T. D. Kim, A. A. Kochman, V. M. Hubbard, S. Lu, J. L. Zakrzewski, T. Ramirez-Montagut, J. M. Eng, S. J. Muriglan, G. Heller, et al. CCR2 is required for CD8-induced graft-versus-host disease Blood, November 1, 2005; 106(9): 3322 - 3330. [Abstract] [Full Text] [PDF]

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