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Blood, 1 May 2005, Vol. 105, No. 9, pp. 3583-3587. Prepublished online as a Blood First Edition Paper on October 19, 2004; DOI 10.1182/blood-2004-08-3001. This Article Full Text (PDF) All Versions of this Article: 2004-08-3001v1 105/9/3583    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ramoner, R. Articles by Thurnher, M. Search for Related Content PubMed PubMed Citation Articles by Ramoner, R. Articles by Thurnher, M. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 4, 2004 Accepted October 3, 2004 Dendritic cell activation by secretory phospholipase A2 Reinhold Ramoner, Thomas Putz, Hubert Gander, Andrea Rahm, Georg Bartsch, Claudia Schaber, and Martin Thurnher* Department of Urology & kompetenzzentrum medizin tirol (kmt), Medical University of Innsbruck, Innsbruck, Austria * Corresponding author; email: martin.thurnher{at}uibk.ac.at. Dendritic cells (DCs), also referred to as the sentinels of the immune system, induce and coordinate important functions of immune surveillance. DCs acquire immunity-initiating capacity only after a process of maturation usually induced by ligands that bind to members of the tumor necrosis factor (TNF) or toll-like receptor families. Secretory phospholipase A2 (sPLA2) which hydrolyzes the sn-2 ester bond of glycerophospholipids regulates a variety of cellular functions including migration of endothelial cells and neurite outgrowth. In the present study we investigated the role of sPLA2 in DC biology. We report that human monocyte-derived DC cultures lack sPLA2 activity but respond to exogenous sPLA2. sPLA2 alone and in co-operation with TNF- and IL-1 induced fatty acid release from DC membranes which was accompanied by up-regulation of surface markers and by an increase in the migratory and immunostimulatory capacity of the DCs. Our findings indicate that secreted enzymes such as sPLA2 can contribute to DC maturation and emphasize the role of lipid mediators in the regulation of immune responses. This observation may also have implications for DC-based vaccine development. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Bobik Secretory phospholipase A2 type IIA: a regulator of immune function in atherosclerosis? Cardiovasc Res, January 1, 2009; 81(1): 9 - 10. [Full Text] [PDF] E. Ibeas, L. Fuentes, R. Martin, M. Hernandez, and M. L. Nieto Secreted phospholipase A2 type IIA as a mediator connecting innate and adaptive immunity: new role in atherosclerosis Cardiovasc Res, January 1, 2009; 81(1): 54 - 63. [Abstract] [Full Text] [PDF] B. P. Hurley and B. A. McCormick Multiple Roles of Phospholipase A2 during Lung Infection and Inflammation Infect. Immun., June 1, 2008; 76(6): 2259 - 2272. [Full Text] [PDF] N L A Misso, N Petrovic, C Grove, A Celenza, J Brooks-Wildhaber, and P J Thompson Plasma phospholipase A2 activity in patients with asthma: association with body mass index and cholesterol concentration Thorax, January 1, 2008; 63(1): 21 - 26. [Abstract] [Full Text] [PDF] M. Thurnher Lipids in dendritic cell biology: messengers, effectors, and antigens J. Leukoc. Biol., January 1, 2007; 81(1): 154 - 160. [Abstract] [Full Text] [PDF]

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