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Blood, 1 June 2005, Vol. 105, No. 11, pp. 4416-4423. Prepublished online as a Blood First Edition Paper on February 22, 2005; DOI 10.1182/blood-2004-08-3156. This Article Full Text (PDF) Supplemental Figures All Versions of this Article: 2004-08-3156v1 105/11/4416    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fernandez, N. C Articles by Raulet, D. H Search for Related Content PubMed PubMed Citation Articles by Fernandez, N. C Articles by Raulet, D. H Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 20, 2004 Accepted January 30, 2005 A subset of natural killer cells achieve self-tolerance without expressing inhibitory receptors specific for self MHC molecules Nadine C Fernandez, Emmanuel Treiner, Russell E Vance, Amanda M Jamieson, Suzanne Lemieux, and David H Raulet* Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California Berkeley, Berkeley, CA, USA Institut National de la Recherche Scientifique-Institut Armand Frappier, Universite du Quebec, Laval, Quebec, Canada * Corresponding author; email: raulet{at}uclink.berkeley.edu. It is widely believed that self-tolerance of NK cells occurs because each NK cell expresses at least one inhibitory receptor specific for a host MHC class I molecule. Here we report that some NK cells lack all known self MHC-specific inhibitory receptors, yet are nevertheless self-tolerant. These NK cells exhibit a normal cell surface phenotype and some functional activity. However, they respond poorly to class I-deficient normal cells, tumor cells, or crosslinking of stimulatory receptors, suggesting that self-tolerance is established by dampening stimulatory signaling. Thus, self-tolerance of NK cells in normal animals can occur independently of MHC-mediated inhibition, and hyporesponsiveness plays a role in self-tolerance of NK cells, as also proposed for B and T cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Marcenaro, C. Cantoni, S. Pesce, C. Prato, D. Pende, S. Agaugue, L. Moretta, and A. Moretta Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction Blood, November 5, 2009; 114(19): 4108 - 4116. [Abstract] [Full Text] [PDF] E. F. Castillo, S. W. 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