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Blood, 15 February 2005, Vol. 105, No. 4, pp. 1417-1423. Prepublished online as a Blood First Edition Paper on October 19, 2004; DOI 10.1182/blood-2004-08-3175. This Article Full Text (PDF) All Versions of this Article: 2004-08-3175v1 105/4/1417    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Marcus, R. Articles by Smith, P. Search for Related Content PubMed PubMed Citation Articles by Marcus, R. Articles by Smith, P. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 17, 2004 Accepted October 11, 2004 CVP chemotherapy plus Rituximab compared with CVP as first-line treatment for advanced follicular lymphoma Robert Marcus*, Kevin Imrie, Andrew Belch, David Cunningham, Eduardo Flores, John Catalano, Philippe Solal-Celigny, Fritz Offner, Jan Walewski, Joao Raposo, Andrew Jack, and Paul Smith Addenbrooke's Hospital, Cambridge, UK Toronto-Sunnybrook Regional Cancer Center, Toronto, Canada Cross Cancer Institute, Edmonton, Canada Royal Marsden Hospital, Surrey, UK Hospital Gregorio Maranon, Madrid, Spain Monash Medical Centre, Clayton, Australia Clinique Victor Hugo, Le Mans, France Dienst Hematologie, UZ Gent, Belgium M. Sklodowska-Curie Memorial Institute, Warszawa, Poland Hospital Santa Maria, Lisboa, Portugal Leeds General Infirmary, Leeds, UK Cancer Research UK and UCL Cancer Trials Centre, London, UK * Corresponding author; email: robert.marcus{at}addenbrookes.nhs.uk. The combination of cyclophosphamide, vincristine, and prednisone (CVP) is one of several standard treatment options for advanced follicular lymphoma. This-like similar chemotherapeutic regimens-induces response rates of 60 to 80%, with a median response duration of under 2 years. Rituximab, a chimeric monoclonal antibody against CD20, is active in follicular lymphoma, both as monotherapy and in combination with chemotherapy. Previously untreated patients with stage III/IV follicular lymphoma were randomly assigned to receive either 8 cycles of CVP plus rituximab (R-CVP; N = 162) or CVP (N = 159). Overall and complete response rates were 81% and 41% in the R-CVP arm vs. 57% and 10% in the CVP arm, respectively (P < 0.0001). At a median follow-up of 30 months, patients treated with R-CVP had a highly significantly prolonged time to progression (median 32 months vs. 15 months for CVP; P < 0.0001). Median time to treatment failure was 27 months in patients receiving R-CVP and 7 months in the CVP arm (P < 0.0001). Rituximab did not add significantly to the toxicity of CVP. The addition of rituximab to the CVP regimen significantly improves the clinical outcome in patients with previously untreated advanced follicular lymphoma, without increased toxicity. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Rituximab and poor-risk follicular lymphoma Craig H. Moskowitz Blood 2005 105: 1380. [Full Text] [PDF] This article has been cited by other articles: C. Sebban, P. Brice, R. Delarue, C. Haioun, B. Souleau, N. Mounier, N. Brousse, P. Feugier, H. Tilly, P. Solal-Celigny, et al. 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