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Blood, 15 February 2005, Vol. 105, No. 4, pp. 1405-1407. Prepublished online as a Blood First Edition Paper on October 21, 2004; DOI 10.1182/blood-2004-08-3178. This Article Full Text (PDF) All Versions of this Article: 2004-08-3178v1 105/4/1405    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hong, K. H Articles by Han, K. H Search for Related Content PubMed PubMed Citation Articles by Hong, K. H Articles by Han, K. H Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 18, 2004 Accepted October 19, 2004 Monocyte chemoattractant protein-1-induced angiogenesis is mediated by vascular endothelial growth factor-A Kyung H Hong, Jewon Ryu, and Ki H Han* Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of * Corresponding author; email: steadyhan{at}amc.seoul.kr. Monocyte chemoattractant protein (MCP)-1 has been recognized as an angiogenic chemokine. In the present study, we investigated the detailed mechanism by which MCP-1 induces angiogenesis. We found that MCP-1 upregulated hypoxia-inducible factor 1 alpha (HIF-1) gene expression in human aortic endothelial cells (HAECs), which induced VEGF-A165 expression in the aortic wall and HAECs through activation of p42/44 MAPK. In vivo angiogenesis assay using chick chorioallantoic membrane (CAM) showed that MCP-1-induced angiogenesis was as potent as that induced by VEGF-A165, and completely inhibited by a VEGF inhibitor, Flt2-11. The inhibition of RhoA small G protein did not affect MCP-1-induced VEGF-A165 production and secretion, but completely blocked both MCP-1- and VEGF-A-induced new vessel formation, as determined by CAM assay. These results suggest that MCP-1-induced angiogenesis is composed of largely two sequential steps; the induction of VEGF-A gene expression by MCP-1 and the subsequent VEGF-A-induced angiogenesis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. W. Younce, A. Azfer, and P. E. Kolattukudy MCP-1 (Monocyte Chemotactic Protein-1)-induced Protein, a Recently Identified Zinc Finger Protein, Induces Adipogenesis in 3T3-L1 Pre-adipocytes without Peroxisome Proliferator-activated Receptor {gamma} J. 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