|
|
Blood, 15 February 2005, Vol. 105, No. 4, pp. 1632-1639.
Prepublished online as a Blood First Edition Paper on October 21, 2004; DOI 10.1182/blood-2004-08-3196.
 Previous Article | Next Article 
Submitted August 19, 2004
Accepted October 13, 2004
Epstein-Barr virus nuclear antigen 2 induces interleukin-18 receptor expression in B-cells
Franck Pages, Jerome Galon, Galina Karaschuk, Diana Dudziak, Mathieu Camus, Vladimir Lazar, Sophie Camilleri-Broet, Christine Lagorce-Pages, Sophie Lebel-Binay, Gerhard Laux, Wolf-Herman Fridman, and Berthold Henglein*
INSERM U 255, Centre de Recherches Biomedicales des Cordeliers, Paris, France; Service d'Immunologie Biologique, Hopital Europeen Georges Pompidou, Paris, France
INSERM U 255, Centre de Recherches Biomedicales des Cordeliers, Paris, France
Institut fur Klinische Molekularbiologie und Tumorgenetik, GSF-Forschungszentrum fur Umwelt und Gesundheit, Munchen, Germany
Unite de Genomique Fonctionnelle, Institut Gustave Roussy, Villejuif, France
INSERM U 255, Centre de Recherches Biomedicales des Cordeliers, Paris, France; Service d'Anatomie Pathologique, Hopital Hotel-Dieu, AP-HP, Paris, France
Service d'Anatomie Pathologique, Hopital Avicenne, AP-HP, Bobigny, France
INSERM U 255, Centre de Recherches Biomedicales des Cordeliers, Paris, France; CNRS UMR 7098, Universite Pierre et Marie Curie, Paris, France
* Corresponding author; email: Berthold.Henglein{at}snv.jussieu.fr.
Epstein-Barr virus (EBV) latently infects and immortalizes B-lymphocytes and causes lymphoproliferative malignancies. We show here that the EBV nuclear antigen EBNA2 induces expression of the two chains of the interleukin-18 receptor (IL-18R) in Burkitt lymphoma (BL) cell lines and in non-transformed B-cells. Activation of IL-18R expression by EBNA2 is independent of its interaction with the transcriptional repressor, RBPJ . It occurs in the absence of any other viral protein but requires de novo synthesis of cellular proteins. IL-18R induction is a highly specific function of EBNA2, since neither other EBV latent proteins, nor the cellular proteins c-myc or Notch can exert this effect. Using cDNA microarray expression profiling, we find that the IL-18 receptor expressed in EBV-infected BL cells has signaling capacity, since IL-18 significantly modified gene expression. We report that EBNA2 expression is associated with IL-18R expression in vivo in EBV-positive B-lymphomas from AIDS patients.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. Orozco, E. Gemmell, M. Bickel, and G.J. Seymour
Interleukin 18 and Periodontal Disease
J. Dent. Res.,
July 1, 2007;
86(7):
586 - 593.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Galon, A. Costes, F. Sanchez-Cabo, A. Kirilovsky, B. Mlecnik, C. Lagorce-Pages, M. Tosolini, M. Camus, A. Berger, P. Wind, et al.
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome.
Science,
September 29, 2006;
313(5795):
1960 - 1964.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Mohan, J. Dement-Brown, S. Maier, T. Ise, B. Kempkes, and M. Tolnay
Epstein-Barr virus nuclear antigen 2 induces FcRH5 expression through CBF1
Blood,
June 1, 2006;
107(11):
4433 - 4439.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Zhao, S. Maruo, A. Cooper, M. R. Chase, E. Johannsen, E. Kieff, and E. Cahir-McFarland
RNAs induced by Epstein-Barr virus nuclear antigen 2 in lymphoblastoid cell lines
PNAS,
February 7, 2006;
103(6):
1900 - 1905.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
