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Blood, 1 February 2005, Vol. 105, No. 3, pp. 1102-1105. Prepublished online as a Blood First Edition Paper on October 5, 2004; DOI 10.1182/blood-2004-08-3253. This Article Full Text (PDF) All Versions of this Article: 2004-08-3253v1 105/3/1102    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lisman, T. Articles by Rosendaal, F. R Search for Related Content PubMed PubMed Citation Articles by Lisman, T. Articles by Rosendaal, F. R Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 25, 2004 Accepted September 27, 2004 Reduced plasma fibrinolytic potential is a risk factor for venous thrombosis Ton Lisman*, Philip G de Groot, Joost C Meijers, and Frits R Rosendaal Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Centre, Utrecht, The Netherlands; Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands; Haemostasis and Thrombosis Research Center, Leiden University Medical Center, Leiden, The Netherlands * Corresponding author; email: j.a.lisman{at}azu.nl. The role of the fibrinolytic system in the development of deep vein thrombosis (DVT) is unclear. We determined the plasma fibrinolytic potential of patients enrolled in the Leiden Thrombophilia Study (LETS), a population-based case-control study on risk factors for DVT. Plasma fibrinolytic potential was determined in 421 patients and 469 control subjects by means of a tissue factor- and tissue-type plasminogen activator (tPA)-induced clot lysis assay. Using clot lysis times above the 70th, 80th, 90th, 95th, and 99th percentile of the values found in control subjects as cut-off levels, we found a dose-dependent increase in risk for DVT in patients with hypofibrinolysis (odds ratios of 1.4, 1.6, 1.9, 2.1, 2.2, respectively). This indicates a two-fold increased risk of DVT in subjects with clot lysis times above the 90th percentile. The risk increase was not affected by age or sex (adjusted odds ratio for 90th percentile 2.0), and after correction for all possible confounders (age, sex, and levels of procoagulant proteins which were shown to associate with clot lysis times in the control population) the risk estimate was marginally reduced (odds ratio 1.6 for 90th percentile). Taken together, these results indicate that plasma hypofibrinolysis constitutes a risk factor for venous thrombosis, with a doubling of the risk at clot lysis times which are present in 10 percent of the population. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. A. Campbell, K. A. Overmyer, C. H. Selzman, B. C. Sheridan, and A. S. Wolberg Contributions of extravascular and intravascular cells to fibrin network formation, structure, and stability Blood, November 26, 2009; 114(23): 4886 - 4896. [Abstract] [Full Text] [PDF] A. Undas, K. Zawilska, M. 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