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Blood, 15 February 2005, Vol. 105, No. 4, pp. 1440-1447. Prepublished online as a Blood First Edition Paper on October 14, 2004; DOI 10.1182/blood-2004-08-3257. This Article Full Text (PDF) All Versions of this Article: 2004-08-3257v1 105/4/1440    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lehar, S. M Articles by Bevan, M. J Search for Related Content PubMed PubMed Citation Articles by Lehar, S. M Articles by Bevan, M. J Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 24, 2004 Accepted October 4, 2004 Notch ligands Delta1 and Jagged1 transmit distinct signals to T cell precursors Sophie M Lehar, James Dooley, Andrew G Farr, and Michael J Bevan* Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, Washington, USA Department of Biological Structure, University of Washington, Seattle, Washington, USA * Corresponding author; email: mbevan{at}u.washington.edu. Signaling through the Notch pathway plays an essential role in inducing T lineage commitment and promoting the maturation of immature thymocytes. Using an in vitro culture system, we show that two different classes of Notch ligands, Jagged1 or Delta1, transmit distinct signals to T cell progenitors. OP9 stromal cells expressing either Jagged1 or Delta1 inhibit the differentiation of DN1 thymocytes into the B cell lineage, but only the Delta1-expressing stromal cells promote the proliferation and maturation of T cell progenitors through the early double negative (DN) stages of thymocyte development. Whereas the majority of bone marrow-derived stem cells do not respond to Jagged1 signals, T cell progenitors respond to Jagged1 signals during a brief window of their development between the DN1 and DN3 stages of thymic development. During these stages, Jagged1 signals can influence the differentiation of immature thymocytes along the NK and T cell lineages. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Cooking up T cells Warren S. Pear Blood 2005 105: 1373-1374. [Full Text] [PDF] This article has been cited by other articles: M. Singh, P. Mukherjee, K. Narayanasamy, R. Arora, S. D. Sen, S. Gupta, K. Natarajan, and P. Malhotra Proteome Analysis of Plasmodium falciparum Extracellular Secretory Antigens at Asexual Blood Stages Reveals a Cohort of Proteins with Possible Roles in Immune Modulation and Signaling Mol. Cell. Proteomics, September 1, 2009; 8(9): 2102 - 2118. [Abstract] [Full Text] [PDF] O. H. Cho, H. M. Shin, L. Miele, T. E. Golde, A. Fauq, L. M. Minter, and B. A. Osborne Notch Regulates Cytolytic Effector Function in CD8+ T Cells J. Immunol., March 15, 2009; 182(6): 3380 - 3389. [Abstract] [Full Text] [PDF] M. Kijima, T. Yamaguchi, C. Ishifune, Y. Maekawa, A. Koyanagi, H. Yagita, S. Chiba, K. Kishihara, M. Shimada, and K. Yasutomo Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction PNAS, May 13, 2008; 105(19): 7010 - 7015. [Abstract] [Full Text] [PDF] V. Parravicini, A.-C. Field, P. D. Tomlinson, M. Albert Basson, and R. Zamoyska Itch-/-{alpha}{beta} and {gamma}{delta} T cells independently contribute to autoimmunity in Itchy mice Blood, April 15, 2008; 111(8): 4273 - 7282. [Abstract] [Full Text] [PDF] F. A. High, M. M. Lu, W. S. Pear, K. M. Loomes, K. H. Kaestner, and J. A. Epstein Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development PNAS, February 12, 2008; 105(6): 1955 - 1959. [Abstract] [Full Text] [PDF] M. Mohtashami and J. C. Zuniga-Pflucker Cutting Edge: Three-Dimensional Architecture of the Thymus Is Required to Maintain Delta-Like Expression Necessary for Inducing T Cell Development J. Immunol., January 15, 2006; 176(2): 730 - 734. [Abstract] [Full Text] [PDF] J. Huang, K. P. Garrett, R. Pelayo, J. C. Zuniga-Pflucker, H. T. Petrie, and P. W. Kincade Propensity of Adult Lymphoid Progenitors to Progress to DN2/3 Stage Thymocytes with Notch Receptor Ligation J. Immunol., October 15, 2005; 175(8): 4858 - 4865. [Abstract] [Full Text] [PDF] C. Delaney, B. Varnum-Finney, K. Aoyama, C. Brashem-Stein, and I. D. Bernstein Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells Blood, October 15, 2005; 106(8): 2693 - 2699. [Abstract] [Full Text] [PDF] M. H. Dallas, B. Varnum-Finney, C. Delaney, K. Kato, and I. D. Bernstein Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells J. Exp. Med., May 2, 2005; 201(9): 1361 - 1366. [Abstract] [Full Text] [PDF]

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