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Blood, 1 May 2005, Vol. 105, No. 9, pp. 3749-3756. Prepublished online as a Blood First Edition Paper on January 6, 2005; DOI 10.1182/blood-2004-08-3312. This Article Full Text (PDF) All Versions of this Article: 2004-08-3312v1 105/9/3749    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sanders, J. E Articles by Appelbaum, F. R Search for Related Content PubMed PubMed Citation Articles by Sanders, J. E Articles by Appelbaum, F. R Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 26, 2004 Accepted December 23, 2004 Allogeneic hematopoietic cell transplantation for infants with acute lymphoblastic leukemia Jean E Sanders*, Ho Joon Im, Paul A Hoffmeister, Ted A Gooley, Ann E Woolfrey, Paul A Carpenter, Robert G Andrews, Eileen M Bryant, and Frederick R Appelbaum Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Biostatistics, University of Washington School of Public Health and Community Medicine, Seattle, WA, USA Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA * Corresponding author; email: jsanders{at}fhcrc.org. The role of transplantation in infants with acute lymphoblastic leukemia (ALL) is not defined. We analyzed results of 40 infants diagnosed before age 12 months who received a hematopoietic cell transplant (HCT) between July 1982 and February 2003 in CR1 (n=17), CR2/3 (n=7) or relapse (n=16). Patients were conditioned with cyclophosphamide with total body irradiation (n=39) or busulfan (n=1). Donors were matched related, (n=8), mismatched related (n=16), or unrelated (n=16). Graft-versus-host disease (GVHD) prophylaxis was methotrexate or cyclosporine (7) or methotrexate plus cyclosporine (33). Thirty-nine engrafted, 20 developed acute GVHD, and 7 chronic GVHD. Sixteen relapsed and seven died of other causes. Patients in CR1 had disease-free survival (DFS) of 76% compared to 45% for CR2/CR3 and 8% for relapse (P=0.0001). Of 33 patients with cytogenetic data, 26 (79%) had MLL gene rearrangement. Fourteen of these 26 were in CR1 and 11 survive in remission. Outcome was associated with phase of disease, but having the MLL gene was not a factor predictive of outcome. Late effects included growth and other hormone deficiencies. These data demonstrate that infants with ALL and MLL gene have excellent DFS when transplanted in CR1 and consideration for transplantation in CR1 is warranted. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J.-M. Ribera, J.-J. Ortega, A. Oriol, P. Bastida, C. Calvo, J.-M. Perez-Hurtado, M.-E. Gonzalez-Valentin, V. Martin-Reina, A. Molines, F. Ortega-Rivas, et al. Comparison of Intensive Chemotherapy, Allogeneic, or Autologous Stem-Cell Transplantation As Postremission Treatment for Children With Very High Risk Acute Lymphoblastic Leukemia: PETHEMA ALL-93 Trial J. Clin. Oncol., January 1, 2007; 25(1): 16 - 24. [Abstract] [Full Text] [PDF] I. Yakoub-Agha, F. Mesnil, M. Kuentz, J. M. Boiron, N. Ifrah, N. Milpied, S. Chehata, H. Esperou, J.-P. Vernant, M. Michallet, et al. Allogeneic Marrow Stem-Cell Transplantation From Human Leukocyte Antigen-Identical Siblings Versus Human Leukocyte Antigen-Allelic-Matched Unrelated Donors (10/10) in Patients With Standard-Risk Hematologic Malignancy: A Prospective Study From the French Society of Bone Marrow Transplantation and Cell Therapy J. Clin. Oncol., December 20, 2006; 24(36): 5695 - 5702. [Abstract] [Full Text] [PDF] B. Triplett, R. Handgretinger, C.-H. Pui, and W. Leung KIR-incompatible hematopoietic-cell transplantation for poor prognosis infant acute lymphoblastic leukemia Blood, February 1, 2006; 107(3): 1238 - 1239. [Full Text] [PDF] C.-H. Pui and W. E. Evans Treatment of Acute Lymphoblastic Leukemia N. Engl. J. Med., January 12, 2006; 354(2): 166 - 178. [Full Text] [PDF] M. Eapen, P. Rubinstein, M.-J. Zhang, B. M. Camitta, C. Stevens, M. S. Cairo, S. M. Davies, J. J. Doyle, J. Kurtzberg, M. A. Pulsipher, et al. Comparable Long-Term Survival After Unrelated and HLA-Matched Sibling Donor Hematopoietic Stem Cell Transplantations for Acute Leukemia in Children Younger Than 18 Months J. Clin. Oncol., January 1, 2006; 24(1): 145 - 151. [Abstract] [Full Text] [PDF] S. Bhatia Cancer Survivorship--Pediatric Issues Hematology, January 1, 2005; 2005(1): 507 - 515. [Abstract] [Full Text] [PDF]

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