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Blood, 15 December 2005, Vol. 106, No. 13, pp. 4287-4293. Prepublished online as a Blood First Edition Paper on August 25, 2005; DOI 10.1182/blood-2004-09-3620. This Article Full Text (PDF) All Versions of this Article: 2004-09-3620v1 106/13/4287    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mathas, S. Articles by Dorken, B. Search for Related Content PubMed PubMed Citation Articles by Mathas, S. Articles by Dorken, B. Related Collections Related Letter in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted September 22, 2004 Accepted August 3, 2005 Elevated NF-B p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large cell, and other peripheral T cell lymphomas Stephan Mathas*, Korinna Johrens, Stefan Joos, Andreas Lietz, Franziska Hummel, Martin Janz, Franziska Jundt, Ioannis Anagnostopoulos, Kurt Bommert, Peter Lichter, Harald Stein, Claus Scheidereit, and Bernd Dorken Max-Delbruck-Center for Molecular Medicine, Berlin, Germany; Hematology, Oncology and Tumorimmunology, Charite, Medical University Berlin, Campus Virchow-Klinikum, Berlin, Germany Institute for Pathology, Charite, Medical University Berlin, Campus Benjamin Franklin, Berlin, Germany German Cancer Research Center, Heidelberg, Germany Hematology, Oncology and Tumorimmunology, Charite, Medical University Berlin, Campus Virchow-Klinikum, Berlin, Germany Max-Delbruck-Center for Molecular Medicine, Berlin, Germany * Corresponding author; email: mathas{at}rrk-berlin.de. Transcription factor NF-B plays a central role in the pathogenesis of classical Hodgkin lymphoma (cHL). In anaplastic large cell lymphomas (ALCLs), which share molecular lesions with cHL, the NF-B system has not been equivalently investigated. Here we describe constitutive NF-B p50 homodimer [(p50)2] activity in ALCL cells in the absence of constitutive activation of the IB kinase (IKK) complex. Furthermore, (p50)2 contributes to the NF-B activity in HRS cells. Bcl-3, which is an inducer of nuclear (p50)2 and is associated with (p50)2 in ALCL and HRS cell lines, is abundantly expressed in ALCL and HRS cells. Notably, a selective overexpression of Bcl-3 target genes is found in ALCL cells. By immunhistochemical screening of 288 lymphoma cases a strong Bcl-3 expression in cHL and in peripheral T cell NHL including ALCL was found. In 3/6 HRS cell lines and 25% of primary ALCL, a copy number increase of the Bcl-3 gene locus was identified. Together, these data suggest that elevated Bcl-3 expression has an important function in cHL and peripheral T-NHL, in particular ALCL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Letter in Blood Online: Chromosomal rearrangements involving the BCL3 locus are recurrent in classical Hodgkin and peripheral T-cell lymphoma Jose I. Martin-Subero, Iwona Wlodarska, Christian Bastard, Jean-Michel Picquenot, Jorge Höppner, Maciej Giefing, Wolfram Klapper, Reiner Siebert, Stephan Mathas, Stefan Joos, Harald Stein, and Bernd Dörken Blood 2006 108: 401-403. [Full Text] [PDF] This article has been cited by other articles: S. Mathas, S. Kreher, K. J. Meaburn, K. Johrens, B. Lamprecht, C. Assaf, W. Sterry, M. E. Kadin, M. Daibata, S. Joos, et al. Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma PNAS, April 7, 2009; 106(14): 5831 - 5836. 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