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Blood, 15 June 2005, Vol. 105, No. 12, pp. 4749-4751. Prepublished online as a Blood First Edition Paper on March 1, 2005; DOI 10.1182/blood-2004-09-3622. This Article Full Text (PDF) All Versions of this Article: 2004-09-3622v1 105/12/4749    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Watanabe, N. Articles by Soumelis, V. Search for Related Content PubMed PubMed Citation Articles by Watanabe, N. Articles by Soumelis, V. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted September 17, 2004 Accepted January 14, 2005 Human TSLP promotes CD40-ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential Norihiko Watanabe, Shino Hanabuchi, Marie-Annick Marloie-Provost, Svetlana Antonenko, Yong-Jun Liu, and Vassili Soumelis* DNAX Research Institute, Palo Alto, CA, USA Immunology, MD Anderson Cancer Center, Houston, Texas, USA * Corresponding author; email: vassili.soumelis{at}curie.net. Interleukin (IL)-4, a major Th2 cytokine, primes dendritic cells (DCs) for IL-12 production, suggesting a negative feedback loop to prevent dysregulated Th2 inflammation, such as allergy. We previously showed that human thymic stromal lymphopoietin (TSLP), highly expressed by keratinocytes of atopic dermatitis, activates CD11c+ DCs to induce the differentiation of naive CD4+ and CD8+ T cells into pro-allergic effectors. Here, we show that TSLP primes DCs to produce large amounts of IL-12 following CD40-ligand stimulation, similar to IL-4 priming of DCs. In contrast to IL-4 priming, DCs activated with TSLP and CD40-ligand induce the differentiation of naive CD4+ T cells into effectors producing both Th1 and Th2 cytokines, a unique profile that is reminiscent of the late phase of allergy. Thus, TSLP is a major regulatory cytokine for IL-12 production by DCs and TSLP-activated DCs could promote the persistence of Th2 inflammation even in the presence of IL-12-inducing signals. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. R. Ramalingam, J. T. Pesce, M. M. Mentink-Kane, S. Madala, A. W. Cheever, M. R. Comeau, S. F. Ziegler, and T. A. Wynn Regulation of Helminth-Induced Th2 Responses by Thymic Stromal Lymphopoietin J. Immunol., May 15, 2009; 182(10): 6452 - 6459. [Abstract] [Full Text] [PDF] E. O. Kvale, Y. Floisand, F. Lund-Johansen, H. Rollag, L. Farkas, S. Ghanekar, P. Brandtzaeg, F. L. Jahnsen, and J. Olweus Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells Blood, April 15, 2007; 109(8): 3369 - 3376. [Abstract] [Full Text] [PDF] S. I. Bogiatzi, I. Fernandez, J.-C. Bichet, M.-A. Marloie-Provost, E. Volpe, X. Sastre, and V. Soumelis Cutting Edge: Proinflammatory and Th2 Cytokines Synergize to Induce Thymic Stromal Lymphopoietin Production by Human Skin Keratinocytes J. Immunol., March 15, 2007; 178(6): 3373 - 3377. [Abstract] [Full Text] [PDF]

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