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Blood, 1 December 2005, Vol. 106, No. 12, pp. 3955-3957. Prepublished online as a Blood First Edition Paper on August 11, 2005; DOI 10.1182/blood-2004-09-3749. This Article Full Text (PDF) All Versions of this Article: 2004-09-3749v1 106/12/3955    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kloosterboer, F. M Articles by Falkenburg, J.H. F Search for Related Content PubMed PubMed Citation Articles by Kloosterboer, F. M Articles by Falkenburg, J.H. F Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted September 28, 2004 Accepted June 19, 2005 Upregulated expression in non-hematopoietic tissues of the BCL2A1-derived minor histocompatibility antigens in response to inflammatory cytokines: relevance for allogeneic immunotherapy of leukemia Freke M Kloosterboer*, Simone A van Luxemburg-Heijs, Ronald A van Soest, H.M. E van Egmond, Roel Willemze, and J.H. F Falkenburg Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands * Corresponding author; email: F.M.Kloosterboer{at}lumc.nl. T cells directed against hematopoietic-restricted minor histocompatibility antigens (mHags) may mediate graft-versus-leukemia (GVL) reactivity without graft-versus-host-disease. Recently, the HLA-A24 restricted mHag ACC-1 and the HLA-B44 restricted mHag ACC-2 encoded by separate polymorphisms within the BCL2A1 gene were characterized. Hematopoietic-restricted expression was suggested for these mHags. We demonstrate BCL2A1 expression in mesenchymal stromal cells (MSC), that was upregulated by inflammatory cytokines TNF and/or IFN. Analysis of cytotoxicity and IFN production illustrated that ACC-2 specific T cells did not recognize untreated MSC or IFN-treated MSC, but showed specific recognition and killing of TNF+IFN-treated MSC. We hypothesize that under steady-state circumstances BCL2A1 specific T cells may exhibit relative specificity for hematopoietic tissue but reactivity against non-hematopoietic cells may occur when inflammatory infiltrates are present. Thus, the role of BCL2A1 specific T cells in differential induction of GVL reactivity and graft-versus-host-disease may depend on the presence of inflammatory responses that may occur during graft-versus-host-disease. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. A. M. van Bergen, M. G. D. Kester, I. Jedema, M. H. M. Heemskerk, S. A. P. van Luxemburg-Heijs, F. M. Kloosterboer, W. A. E. Marijt, A. H. de Ru, M. R. Schaafsma, R. Willemze, et al. Multiple myeloma-reactive T cells recognize an activation-induced minor histocompatibility antigen encoded by the ATP-dependent interferon-responsive (ADIR) gene Blood, May 1, 2007; 109(9): 4089 - 4096. [Abstract] [Full Text] [PDF] D. Blaise, N. Vey, C. Faucher, and M. Mohty Current status of reduced intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia Haematologica, April 1, 2007; 92(4): 533 - 541. [Abstract] [Full Text] [PDF]

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