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Blood, 1 October 2005, Vol. 106, No. 7, pp. 2444-2451. Prepublished online as a Blood First Edition Paper on June 7, 2005; DOI 10.1182/blood-2004-09-3759. This Article Full Text (PDF) All Versions of this Article: 2004-09-3759v1 106/7/2444    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Jarrett, R. F Articles by Taylor, P. R Search for Related Content PubMed PubMed Citation Articles by Jarrett, R. F Articles by Taylor, P. R Related Collections Related Letter in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted September 29, 2004 Accepted May 15, 2005 Impact of tumour Epstein-Barr virus status on presenting features and outcome in age-defined subgroups of patients with classical Hodgkin lymphoma: a population-based study Ruth F Jarrett, Gail L Stark*, Jo White, Brian Angus, Freda E Alexander, Andrew S Krajewski, June Freeland, Graham M Taylor, and Penelope R Taylor LRF Virus Centre, Institute of Comparative Medicine, University of Glasgow, Glasgow, United Kingdom Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom University of Edinburgh, Edinburgh, United Kingdom Northampton General NHS Trust, Northampton, United Kingdom St Mary's Hospital, Manchester, United Kingdom * Corresponding author; email: g.l.stark{at}ncl.ac.uk. The association between tumour EBV status and clinical outcome in Hodgkin lymphoma (HL) is controversial. This population-based study assessed the impact of EBV status on survival in age-stratified cohorts of adults with classical HL (cHL). Data from 437 cases were analysed with a median follow-up of 93 months. Overall survival (OS) was significantly better for EBV-negative compared to EBV-positive patients (p< 0.0001) with 5 year survival rates of 81% and 66% respectively; disease-specific survival (DSS) was also greater for EBV-negative patients (p=0.03). The impact of EBV status varied with age at diagnosis. In patients aged 16-34 years, EBV-associated cases had a survival advantage compared to EBV-negative cases but differences were not statistically significance (p=0.21). Among patients aged 50 years, EBV-positivity was associated with a significantly poorer outcome (p=0.003). Excess deaths occurred in EBV-positive patients with both early and advanced stage disease. In multivariate analysis of OS in the older patients, EBV status retained statistical significance after adjusting for the effects of sex, stage and B symptoms (p=0.01). Impaired immune status may contribute to the development of EBV-positive cHL in older patients and strategies aimed at boosting the immune response should be investigated in the treatment of these patients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Letter in Blood Online: Impact of LMP-1 expression on clinical outcome in age-defined subgroups of patients with classical Hodgkin lymphoma Marco Herling, George Z. Rassidakis, Theodoros P. Vassilakopoulos, L. Jeffrey Medeiros, Andreas H. Sarris on behalf of the International Hodgkin Lymphoma Study Group, Ruth F. Jarrett, Gail L. Stark, Jo White, Brian Angus, Freda E. Alexander, Andrew S. Krajewski, June Freeland, G. Malcolm Taylor, and Penelope R. A. Taylor Blood 2006 107: 1240-1241. [Full Text] [PDF] This article has been cited by other articles: R. M'kacher, L. Andreoletti, S. Flamant, F. Milliat, T. Girinsky, J. Dossou, D. Violot, E. Assaf, B. Clausse, S. Koscielny, et al. JC human polyomavirus is associated to chromosomal instability in peripheral blood lymphocytes of Hodgkin's lymphoma patients and poor clinical outcome Ann. Onc., October 13, 2009; (2009) mdp375v1. [Abstract] [Full Text] [PDF] A. Diepstra, G. W. van Imhoff, M. Schaapveld, H. Karim-Kos, A. van den Berg, E. Vellenga, and S. Poppema Latent Epstein-Barr Virus Infection of Tumor Cells in Classical Hodgkin's Lymphoma Predicts Adverse Outcome in Older Adult Patients J. Clin. Oncol., August 10, 2009; 27(23): 3815 - 3821. [Abstract] [Full Text] [PDF] N. Asano, K. Yamamoto, J.-I. Tamaru, T. Oyama, F. Ishida, K. Ohshima, T. Yoshino, N. Nakamura, S. Mori, O. Yoshie, et al. 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[Abstract] [Full Text] [PDF] S. Park, J. Lee, Y. H. Ko, A. Han, H. J. Jun, S. C. Lee, I. G. Hwang, Y. H. Park, J. S. Ahn, C. W. Jung, et al. The impact of Epstein-Barr virus status on clinical outcome in diffuse large B-cell lymphoma Blood, August 1, 2007; 110(3): 972 - 978. [Abstract] [Full Text] [PDF] H. Hjalgrim, K. Ekstrom Smedby, K. Rostgaard, D. Molin, S. Hamilton-Dutoit, E. T. Chang, E. Ralfkiaer, C. Sundstrom, H.-O. Adami, B. Glimelius, et al. Infectious Mononucleosis, Childhood Social Environment, and Risk of Hodgkin Lymphoma Cancer Res., March 1, 2007; 67(5): 2382 - 2388. [Abstract] [Full Text] [PDF] L. Dong, Y. Masaki, T. Takegami, T. Kawanami, K. Itoh, Z.-X. Jin, C.-R. Huang, X.-P. Tong, T. Fukushima, M. Tanaka, et al. Cloning and expression of two human recombinant monoclonal Fab fragments specific for EBV viral capsid antigen Int. Immunol., March 1, 2007; 19(3): 331 - 336. [Abstract] [Full Text] [PDF] N. Asano, A. Oshiro, K. Matsuo, Y. Kagami, F. Ishida, R. Suzuki, T. Kinoshita, Y. Shimoyama, J.-I. Tamaru, T. Yoshino, et al. Prognostic Significance of T-Cell or Cytotoxic Molecules Phenotype in Classical Hodgkin's Lymphoma: A Clinicopathologic Study J. Clin. Oncol., October 1, 2006; 24(28): 4626 - 4633. [Abstract] [Full Text] [PDF] M. Herling, G. Z. Rassidakis, T. P. Vassilakopoulos, L. J. Medeiros, A. H. Sarris, on behalf of the International Hodgkin Lymphoma St, R. F. Jarrett, G. L. Stark, J. White, B. Angus, et al. Impact of LMP-1 expression on clinical outcome in age-defined subgroups of patients with classical Hodgkin lymphoma Blood, February 1, 2006; 107(3): 1240 - 1241. [Full Text] [PDF] S. Poppema Immunobiology and Pathophysiology of Hodgkin Lymphomas Hematology, January 1, 2005; 2005(1): 231 - 238. [Abstract] [Full Text] [PDF]

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