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Blood, 1 May 2005, Vol. 105, No. 9, pp. 3449-3457. Prepublished online as a Blood First Edition Paper on January 18, 2005; DOI 10.1182/blood-2004-09-3785. This Article Full Text (PDF) All Versions of this Article: 2004-09-3785v1 105/9/3449    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lee, S. Articles by Kim, C.-C. Search for Related Content PubMed PubMed Citation Articles by Lee, S. Articles by Kim, C.-C. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 1, 2004 Accepted December 30, 2004 The impact of first-line imatinib interim therapy on the outcome of allogeneic stem cell transplantation in adults with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia Seok Lee*, Yoo-Jin Kim, Chang-Ki Min, Hee-Je Kim, Ki-Sung Eom, Dong-Wook Kim, Jong-Wook Lee, Woo-Sung Min, and Chun-Choo Kim Catholic Hematopoietic Stem Cell Transplantation Center, Department of Hematology, College of Medicine, The Catholic University of Korea, Seoul, Korea * Corresponding author; email: leeseok{at}catholic.ac.kr. Previously, we suggested that imatinib incorporation into conventional chemotherapy as an alternative (imatinib interim therapy) might be a useful strategy for bridging the time to allogeneic stem cell transplantation (SCT) for newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Here, we provide an updated report on this strategy in 29 patients. At the time of enrollment, 23 patients (79.3%) achieved complete remission (CR). After the first imatinib cycle, the median BCR-ABL/ABL ratios decreased by 0.77 logs in 25 (86.2%) responders, and their BCR-ABL/ABL ratios decreased further by 0.34 logs after the second imatinib cycle, which included 7 molecular CR. One patient (4.3%) relapsed during the imatinib therapy. The remaining 3 patients were primarily refractory to both imatinib and chemotherapy. Twenty-five (86.2%) of the 29 patients were transplanted in first CR. With a median follow-up duration of 25 months after SCT, the 3-year estimated probabilities of relapse, non-relapse mortality, disease-free survival, and overall survival were 3.8%, 18.7%, 78.1%, and 78.1%, respectively. In comparison to our historical control data, first-line imatinib interim therapy appears provide a good quality of CR and a survival advantage for Ph+ ALL patients. Further long-term follow-up is needed to validate the results of this study. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Ph+ ALL: another success for imatinib Richard T. Maziarz Blood 2005 105: 3388-3389. [Full Text] [PDF] This article has been cited by other articles: S. M. O'Brien, D. A. Thomas, and S. Faderl A La Carte Therapy of Specific Acute Lymphocytic Leukemia Subsets ASCO Educational Book, January 1, 2009; 2009(1): 365 - 370. [Abstract] [Full Text] [PDF] I. Iacobucci, A. Lonetti, F. Messa, D. Cilloni, F. Arruga, E. 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