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Blood, 1 April 2005, Vol. 105, No. 7, pp. 2677-2684. Prepublished online as a Blood First Edition Paper on December 9, 2004; DOI 10.1182/blood-2004-10-3883. This Article Full Text (PDF) All Versions of this Article: 2004-10-3883v1 105/7/2677    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dreyling, M. Articles by Hiddemann, W. Search for Related Content PubMed PubMed Citation Articles by Dreyling, M. Articles by Hiddemann, W. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 6, 2004 Accepted November 28, 2004 Early consolidation by myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission significantly prolongs progression-free survival in mantle cell lymphoma - results of a prospective randomized trial of the European MCL network Martin Dreyling, Georg Lenz, Eva Hoster, Achiel Van Hoof, Christian Gisselbrecht, Rudolf Schmits, Bernd Metzner, Lorenz Truemper, Marcel Reiser, Hjalmar Steinhauer, Jean-Michel Boiron, Marc A Boogaerts, Ali Aldaoud, Vittorio Silingardi, Hanneke C Kluin-Nelemans, Joerg Hasford, Reza Parwaresch, Michael Unterhalt, and Wolfgang Hiddemann* Department of Internal Medicine III, Ludwig-Maximilians University, Munich, Germany Department of Internal Medicine III, Ludwig-Maximilians University, Munich, Germany; Department of Medical Informatics, Biometrics and Epidemiology (IBE), Ludwig-Maximilians University, Munich, Germany Department of Hematology, Hopital St-Jan, Brugge, Belgium Department of Hematology, Hopital Saint Louis, Paris, France Department of Hematology and Oncology, University of Saarland, Homburg/Saar, Germany Department of Internal Medicine II, Klinikum Oldenburg, Oldenburg, Germany Department of Hematology and Oncology, Georg August University, Goettingen, Germany Department of Internal Medicine I, University of Cologne, Cologne, Germany Department of Internal Medicine II, Carl-Thiem Klinikum, Cottbus, Germany CHU Bordeaux, University of Bordeaux, Bordeaux, France Department of Hematology, University Hospital Gasthuisberg, Leuven, Belgium Praxis fur Hamatologie/Onkologie, Leipzig, Germany Department of Medical Oncology, University of Modena, Modena, Italy Department of Hematology, University Medical Center Groningen, Groningen, The Netherlands Department of Medical Informatics, Biometrics and Epidemiology (IBE), Ludwig-Maximilians University, Munich, Germany Department of Hematopathology, University of Kiel, Kiel, Germany * Corresponding author; email: wolfgang.hiddemann{at}med.uni-muenchen.de. Mantle cell lymphoma (MCL) is characterized by poor prognosis with a median survival of only 3-4 years. To improve clinical outcome, the European MCL Network initiated a randomized trial, comparing consolidation with myeloablative radiochemotherapy followed by autologous stem cell transplantation (ASCT) to -interferon maintenance (IFN) in first remission. Patients up to 65 years of age with advanced stage MCL were assigned to ASCT or IFN after achievement of complete or partial remission by a CHOP-like induction therapy. According to the International Prognostic Index (IPI) 43% of patients had a low-risk, 41% a low-intermediate, 11% a high-intermediate and 6% a high risk profile. 62 of 122 patients proceeded to ASCT and 60 received IFN. Patients in the ASCT arm experienced a significantly longer progression-free survival (PFS) with a median of 39 months compared to 17 months for patients in the IFN arm (p = 0.0108). The three year overall survival (OS) was 83% after ASCT vs. 77% in the IFN group (p = 0.18). Early consolidation by myeloablative radiochemotherapy followed by ASCT is feasible and results in a significant prolongation of PFS in advanced stage MCL. Longer follow-up is needed to determine the effect on OS. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. L. Kasamon, R. J. Jones, R. A. Brodsky, E. J. Fuchs, W. Matsui, L. Luznik, J. D. Powell, A. L. Blackford, A. Goodrich, C. D. Gocke, et al. Immunologic recovery following autologous stem-cell transplantation with pre- and posttransplantation rituximab for low-grade or mantle cell lymphoma Ann. Onc., October 30, 2009; (2009) mdp484v1. [Abstract] [Full Text] [PDF] F. Morschhauser, M. Dreyling, A. Rohatiner, F. Hagemeister, and A. 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