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Blood, 15 September 2005, Vol. 106, No. 6, pp. 1965-1974. Prepublished online as a Blood First Edition Paper on June 9, 2005; DOI 10.1182/blood-2004-10-3975. This Article Full Text (PDF) Supplemental Tables All Versions of this Article: 2004-10-3975v1 106/6/1965    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Jacquelin, B. Articles by Tronik-Le Roux, D. Search for Related Content PubMed PubMed Citation Articles by Jacquelin, B. Articles by Tronik-Le Roux, D. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 15, 2004 Accepted May 16, 2005 A novel pathway for megakaryocyte production following in vivo conditional eradication of integrin IIb expressing cells Beatrice Jacquelin, Thierry Kortulewski, Pierre Vaigot, Alexandre Pawlik, Gaetan Gruel, Olivier Alibert, Pascal Soularue, Christophe Joubert, Xavier Gidrol, and Diana Tronik-Le Roux* Laboratoire de Genomique et Radiobiologie de l'Hematopoiese, Service de Genomique Fonctionnelle, Evry, France Laboratoire d'Exploration Fonctionnelle des Genomes, Service de Genomique Fonctionnelle, Evry, France Laboratoire de Cancerologie Experimentale, Commissariat a l'Energie Atomique, Fontenay-aux-Roses, France * Corresponding author; email: diana.le-roux{at}cea.fr. Our knowledge of the molecular mechanisms that regulate hematopoiesis in both, physiological and pathological conditions is limited. Using a molecular approach based on cDNA microarrays, we demonstrate the emergence of an alternative pathway for mature bone marrow cells recovery following the programmed and reversible eradication of CD41+ cells in transgenic mice expressing a conditional toxigene targeted by the platelet IIb promoter. The expression profile of the newly produced CD41+ cells showed high levels of transcripts encoding Ezh2, TdT, Rag2, and various immunoglobulin heavy chains. In this context, we identified and characterized a novel population of Lin-Sca-1hic-Kit- cells, with a lymphoid-like expression pattern, potentially involved in the reconstitution process. Our study revealed novel transcriptional cross-talk between myeloid and lymphoid lineages and identified gene expression modifications that occur in vivo under these particular stress conditions, opening important prospects for therapeutic applications. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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