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Blood, 15 July 2005, Vol. 106, No. 2, pp. 566-571. Prepublished online as a Blood First Edition Paper on March 22, 2005; DOI 10.1182/blood-2004-10-4035. This Article Full Text (PDF) All Versions of this Article: 2004-10-4035v1 106/2/566    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Vitale, M. Articles by Moretta, A. Search for Related Content PubMed PubMed Citation Articles by Vitale, M. Articles by Moretta, A. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 20, 2004 Accepted March 10, 2005 NK-dependent DC maturation is mediated by TNF and IFN released upon engagement of the NKp30 triggering receptor Massimo Vitale, Mariella Della Chiesa, Simona Carlomagno, Daniela Pende, Maurizio Arico, Lorenzo Moretta, and Alessandro Moretta* IST, Istituto Scientifico per la Ricerca sul Cancro, Genova, Italy DI.ME.S. Dipartimento di Medicina Sperimentale, Universita di Genova, Genova, Italy Onco Ematologia Pediatrica, Ospedale dei Bambini G. Di Cristina, Palermo, Italy DI.ME.S. Dipartimento di Medicina Sperimentale, Universita di Genova, Genova, Italy; Istituto Giannina Gaslini, Genova-Quarto, Italy; Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy DI.ME.S. Dipartimento di Medicina Sperimentale, Universita di Genova, Genova, Italy; Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy * Corresponding author; email: alemoret{at}unige.it. NK cells were recently shown to play a relevant role in the process of DC maturation. This function is exerted either by direct DC stimulation or through killing of those DC that did not properly acquire a mature phenotype. While killing of immature DC is dependent on the function of the NKp30 triggering receptor, the mechanism by which NK cells induce DC maturation is still unclear. In this study we show that also the NK-mediated induction of DC maturation is dependent on NKp30. Upon NK/DC interaction, resulting in NKp30 engagement, NK cells produced TNF (and INF) that, in turn, promoted DC maturation. Masking of NKp30 with specific mAbs strongly reduced maturation of DCs cocultured with NK cells. In addition, supernatants from NK cells stimulated via NKp30, induced DC maturation and this effect was neutralized by anti TNF Abs. This NKp30 function is controlled by the HLA-specific inhibitory NK receptors. Accordingly, the ability to promote maturation was essentially confined to NK cells expressing the KIR- NKG2Adull phenotype. Finally, the analysis of perforin-deficient NK cells allowed the dissection of the two NKp30-mediated NK cell functions, since NKp30 could induce cytokine-dependent DC maturation in the absence of NK-mediated DC killing. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. S. Brandt, M. Baratin, E. C. Yi, J. Kennedy, Z. Gao, B. Fox, B. Haldeman, C. D. Ostrander, T. Kaifu, C. Chabannon, et al. The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans J. Exp. Med., July 6, 2009; 206(7): 1495 - 1503. 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