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Blood, 1 July 2005, Vol. 106, No. 1, pp. 201-206.
Prepublished online as a Blood First Edition Paper on March 17, 2005; DOI 10.1182/blood-2004-11-4240.
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Submitted November 5, 2004
Accepted March 6, 2005
A CD8 -11b+ dendritic cells but not CD8+ dendritic cells mediate cross-tolerance toward intestinal antigens
Yeonseok Chung, Jae-Hoon Chang, Mi-Na Kweon, Paul D Rennert, and Chang-Yuil Kang*
Laboratory of Immunology, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea, Republic of
Mucosal Immunology Section, International Vaccine Institute, Seoul, Korea, Republic of
Department of Immunology, Biogen Idec, Cambridge, MA, USA
* Corresponding author; email: cykang{at}snu.ac.kr.
Cross-presentation is a critical process by which antigen is displayed to CD8 T cells to induce tolerance. It is believed that CD8 + dendritic cells (DC) are responsible for cross-presentation, suggesting that the CD8+ DC population is capable of inducing both cross-priming and cross-tolerance to antigen. We found that cross-tolerance against intestinal soluble antigen was abrogated in C57BL/6 mice lacking mesenteric lymph nodes (MLN) and Peyer's patches (PP), whereas mice lacking PP alone were capable of developing CD8 T cell tolerance. CD8-CD11b+ DCs but not CD8+ DCs in the MLN present intestinal antigens to relevant CD8 T cells while CD8+ DCs but not CD8-CD11b+ DCs in the spleen exclusively cross-present intravenous soluble antigen. Thus CD8-CD11b+ DCs in the MLN play a critical role for induction of cross-tolerance to dietary proteins.
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