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Blood, 1 December 2005, Vol. 106, No. 12, pp. 3995-4001. Prepublished online as a Blood First Edition Paper on August 18, 2005; DOI 10.1182/blood-2004-11-4338. This Article Full Text (PDF) All Versions of this Article: 2004-11-4338v1 106/12/3995    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lin, M.-T. Articles by Hansen, J. A Search for Related Content PubMed PubMed Citation Articles by Lin, M.-T. Articles by Hansen, J. A Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 15, 2004 Accepted July 28, 2005 Genetic variation in the IL-10 pathway modulates severity of acute graft-versus-host disease following hematopoietic cell transplantation. Synergism between IL-10 genotype of patient and IL-10 receptor- genotype of donor Ming-Tseh Lin, Barry Storer, Paul J Martin, Li-Hui Tseng, Bryan Grogan, Pei-Jer Chen, Lue P Zhao, and John A Hansen* The Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Pathology, The Albany Medical Center, Albany, NY, USA The Fred Hutchinson Cancer Research Center, Seattle, WA, USA The Fred Hutchinson Cancer Research Center, Seattle, WA, USA; School of Medicine, The University of Washington, Seattle, WA, USA Department of Medical Genetics & Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan College of Medicine, Graduate Institutes of Clinical Medicine, National Taiwan University, Taipei, Taiwan * Corresponding author; email: jhansen{at}fhcrc.org. We have previously shown that the IL-10/-592*A allele of the recipient is associated with less severe acute graft-versus-host disease (GVHD) and a lower risk of non-relapse mortality after hematopoietic cell transplantation (HCT) from an HLA-identical sibling. In the present study, we evaluated examined variation in the IL-10 receptor gene as a further test of the hypothesis that the IL-10 pathway regulates the risk of acute GVHD. A single nucleotide polymorphism (A/G) at cDNA position 238 of the IL-10 receptor gene (IL-10RB/c238) was genotyped in 953 HCT recipients and their HLA-identical sibling donors. IL-10/-592 and IL-10RB/c238 genotypes were tested for association with GVHD by multivariable analysis. The IL-10/-592*A allele of the recipient and IL-10RB/c238*G allele of the donor were significantly associated with a lower risk of grades III-IV acute GVHD (trend p values 0.0008 and 0.02, respectively). The donor IL-10RB/c238*G allele provided protection among patients with the IL-10/-592 A/C or A/A genotypes but not among patients with the high risk IL-10/-592 C/C genotype. These data suggest an interaction of the patient IL-10/-592 and donor IL-10RB/c238 genotypes on risk of GVHD, further supporting the hypothesis that the IL-10 pathway plays an important role in controlling the severity of acute GVHD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. Serafini, M. Andreani, M. Testi, M. Battarra, A. Bontadini, E. Biral, K. Fleischhauer, S. Marktel, G. Lucarelli, M. G. Roncarolo, et al. Type 1 regulatory T cells are associated with persistent split erythroid/lymphoid chimerism after allogeneic hematopoietic stem cell transplantation for thalassemia Haematologica, October 1, 2009; 94(10): 1415 - 1426. [Abstract] [Full Text] [PDF] P.-Y. Bochud, J. W. Chien, K. A. Marr, W. M. Leisenring, A. Upton, M. Janer, S. D. Rodrigues, S. Li, J. A. Hansen, L. P. Zhao, et al. Toll-like Receptor 4 Polymorphisms and Aspergillosis in Stem-Cell Transplantation N. Engl. J. Med., October 23, 2008; 359(17): 1766 - 1777. [Abstract] [Full Text] [PDF] A. Mullally and J. Ritz Beyond HLA: the significance of genomic variation for allogeneic hematopoietic stem cell transplantation Blood, February 15, 2007; 109(4): 1355 - 1362. [Abstract] [Full Text] [PDF] S. Takahashi, J. Ooi, A. Tomonari, T. Konuma, N. Tsukada, M. Oiwa-Monna, K. Fukuno, M. Uchiyama, K. Takasugi, T. Iseki, et al. Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regimen Blood, February 1, 2007; 109(3): 1322 - 1330. [Abstract] [Full Text] [PDF]

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