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Blood, 15 July 2005, Vol. 106, No. 2, pp. 444-446.
Prepublished online as a Blood First Edition Paper on March 31, 2005; DOI 10.1182/blood-2004-11-4353.
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Submitted November 15, 2004
Accepted March 19, 2005
Disparate lymphoid chemokine expression in mice and men: no evidence of CCL21 synthesis by human high endothelial venules
Hege S Carlsen*, Guttorm Haraldsen, Per Brandtzaeg, and Espen S Baekkevold
Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute and Department of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway; Department of Surgery, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute and Department of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
* Corresponding author; email: hege.carlsen{at}klinmed.uio.no.
T cell homing to secondary lymphoid tissues generally depends on chemokine-induced firm adhesion in high endothelial venules (HEVs), and is primarily mediated through the CC chemokine receptor (CCR)7 on lymphocytes. The CCR7 ligand designated CCL21 is considered the most important trigger, as it appears constitutively expressed by murine HEVs. Surprisingly, when we analyzed human tissues, no CCL21 mRNA could be detected in HEVs. In fact, CCL21 mRNA was only expressed in extravascular T zone cells and lymphatics, whereas immunostaining revealed CCL21 protein also within HEVs. This suggests that T cell recruitment to human lymphoid tissues depends on transcytosis of lymphoid chemokines through HEV cells because there is at present no evidence of alternative chemokine production in these cells that could explain attraction of naive T lymphocytes.
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