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Blood, 1 August 2005, Vol. 106, No. 3, pp. 1021-1030. Prepublished online as a Blood First Edition Paper on April 12, 2005; DOI 10.1182/blood-2004-11-4512. This Article Full Text (PDF) Supplemental Tables All Versions of this Article: 2004-11-4512v1 106/3/1021    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by MOREAUX, J. Articles by KLEIN, B. Search for Related Content PubMed PubMed Citation Articles by MOREAUX, J. Articles by KLEIN, B. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 30, 2004 Accepted April 2, 2005 The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature Jerome MOREAUX, friedrich W CREMER, Thierry REME, Marc RAAB, Karene MAHTOUK, Philine KAUKEL, Veronique PANTESCO, John DE VOS, Eric JOURDAN, Anna JAUCH, Eric LEGOUFFE, Marion MOOS, Genevieve FIOL, Hartmut GOLDSCHMIDT, Jean Francois ROSSI, Dirk HOSE, and Bernard KLEIN* INSERM U475 and Unit for Cellular Therapy, CHU Montpellier, Hopital St Eloi, Montpellier, France Medizinische Klinik und Poliklinik V, Universitatsklinikum Heidelberg, Heidelberg, Germany; Institut fur Humangenetik, Universitatsklinikum Heidelberg, Heidelberg, Germany Medizinische Klinik und Poliklinik V, Universitatsklinikum Heidelberg, Heidelberg, Germany Internal Medicine Department B, CHU de Nimes, Nimes, France Institut fur Humangenetik, Universitatsklinikum Heidelberg, Heidelberg, Germany Clinical Hematology Department, CHU Montpellier, Hopital Lapeyronie, Montpellier, France * Corresponding author; email: klein{at}montp.inserm.fr. BAFF and APRIL have been shown to promote multiple myeloma (MM) cell growth. We show that the main site of production for BAFF and APRIL is the bone marrow (BM) environment, mainly by monocytes and neutrophils. In addition, osteoclasts produce very high levels of APRIL, unlike BM stromal cells. Myeloma cells (MMC) express TACI, the receptor of BAFF/APRIL at varying levels. TACI expression is a good indicator of a BAFF-binding receptor. Expression data of purified MMC from 65 newly-diagnosed patients have been generated using Affymetrix microarrays and were analyzed by supervised clustering of groups with higher (TACIhigh) vs. lower TACI (TACIlow) expression levels. Patients in the TACIlow group had clinical parameters associated with bad prognosis. A set of 659 genes was differentially expressed between TACIhigh and TACIlow MMC. This set makes it possible to efficiently classify TACIhigh and TACIlow MMC in an independent cohort of 40 patients. TACIhigh MMC displayed a mature plasma cell gene signature, indicating dependence on the BM environment. In contrast, the TACIlow group had a gene signature of plasmablasts suggesting an attenuated dependence on the BM environment. Taken together, our findings suggest using gene expression profiling to identify the group of patients which might benefit most from treatment with BAFF/APRIL inhibitors. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: APRIL showers cause CLL and myeloma to flower John Shaughnessy, Jr Blood 2005 106: 766-767. [Full Text] [PDF] This article has been cited by other articles: D. Hose, J. Moreaux, T. Meissner, A. Seckinger, H. Goldschmidt, A. Benner, K. Mahtouk, J. Hillengass, T. Reme, J. De Vos, et al. Induction of angiogenesis by normal and malignant plasma cells Blood, July 2, 2009; 114(1): 128 - 143. [Abstract] [Full Text] [PDF] M. Gupta, S. R. Dillon, S. C. Ziesmer, A. L. Feldman, T. E. 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