SEARCH:   Advanced

Blood, 15 August 2005, Vol. 106, No. 4, pp. 1495-1500. Prepublished online as a Blood First Edition Paper on May 5, 2005; DOI 10.1182/blood-2004-11-4557. This Article Full Text (PDF) All Versions of this Article: 2004-11-4557v1 106/4/1495    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cahn, J.-Y. Articles by Socie, G. Search for Related Content PubMed PubMed Citation Articles by Cahn, J.-Y. Articles by Socie, G. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 1, 2004 Accepted April 15, 2005 Prospective evaluation of two acute graft-versus-host (GVHD) grading systems: A joint Societe Francaise de Greffe de Moelle et Therapie Cellulaire (SFGM-TC), Dana Farber Cancer Institute (DFCI) and International Bone Marrow Transplant Registry (IBMTR) prospective study Jean-Yves Cahn*, John P Klein, Stephanie J Lee, Noel Milpied, Didier Blaise, Joseph H Antin, Veronique Leblond, Norbert Ifrah, Jean- Pierre Jouet, Fausto Loberiza, Olle Ringden, A J Barrett, Mary M Horowitz, and Gerard Socie Hematology Department, Centre Hospitalo-Universitaire, Grenoble, France International Bone Marrow Transplant Registry, Medical College of Wisconsin, Milwaukee, WI, USA Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA Hematology Department, Centre Hospitalo-Universitaire, Nantes, France Hematology Department, Institut Paoli-Calmettes, Marseille, France Hematology Department, Hopital La Pitie Salpetriere, Paris, France Hematology Department, Centre Hospitalo-Universitaire Angers, Angers, France Hematology Department, Centre Hospitalo-Universitaire Lille, Lille, France Huddinge University Hospital, Stockholm, Sweden National Institute of Health, Bethesda, MD, USA Hopital Saint-Louis, Paris, France * Corresponding author; email: JYCahn{at}chu-grenoble.fr. The most commonly used grading system for acute graft-versus-host disease (aGVHD) was introduced thirty years ago by Glucksberg; a revised system was developed by the International Bone Marrow Transplant Registry (IBMTR) in 1997. To prospectively compare the two classifications and to evaluate the effect of duration and severity of aGVHD on survival, we conducted a multicenter study of 607 patients receiving T cell replete allografts, scored weekly for aGVHD in 18 transplant centers. Sixty-nine percent of donors were HLA-identical siblings and 28%, unrelated donors. The conditioning regimen included total body irradiation in 442 (73%) patients. The two classifications performed similarly in explaining variability in survival by aGVHD grade though the Glucksberg classification predicted early survival better. There was less physician bias or error in assigning grades with the IBMTR scoring system. With either system, only maximum observed grade had prognostic significance for survival; neither time of onset nor progression from an initially lower grade of aGVHD was associated with survival once maximum grade was considered. Regardless of scoring system, aGVHD severity accounted for only a small percentage of observed variation in survival. Validity of these results in populations receiving peripheral blood transplants or non-myeloablative conditioning regimens remains to be tested. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Paczesny, T. M. Braun, J. E. Levine, J. Hogan, J. Crawford, B. Coffing, S. Olsen, S. W. Choi, H. Wang, V. Faca, et al. Elafin Is a Biomarker of Graft-Versus-Host Disease of the Skin Science Translational Medicine, January 6, 2010; 2(13): 13ra2 - 13ra2. [Abstract] [Full Text] [PDF] S. Pavletic aGVHDAI: escape from the silo Blood, July 15, 2006; 108(2): 412 - 413. [Full Text] [PDF] W. M. Leisenring, P. J. Martin, E. W. Petersdorf, A. E. Regan, N. Aboulhosn, J. M. Stern, S. N. Aker, R. C. Salazar, and G. B. McDonald An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens Blood, July 15, 2006; 108(2): 749 - 755. [Abstract] [Full Text] [PDF]

	Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020