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Blood, 1 January 2006, Vol. 107, No. 1, pp. 410-412.
Prepublished online as a Blood First Edition Paper on September 13, 2005; DOI 10.1182/blood-2004-11-4565.
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Submitted December 8, 2004
Accepted August 12, 2005
Peyer's patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantation
Lisbeth A Welniak*, Dmitry V Kuprash, Alexei V Tumanov, Angela Panoskaltsis-Mortari, Bruce R Blazar, Kai Sun, Sergei A Nedospasov, and William J Murphy
Department of Microbiology and Immunology, University of Nevada Medical School, Reno, NV, USA
Laboratory of Molecular Immunology, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
Cancer Center and Department of Pediatrics, Division of BMT, University of Minnesota, Minneapolis, MN, USA
Laboratory of Molecular Immunology, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; Basic Research Program, SAIC-Frederick, Inc., Frederick, MD, USA; Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA
* Corresponding author; email: lwelniak{at}unr.edu.
Graft-versus-Host Disease (GVHD) is a multi-step disease process following allogeneic bone marrow transplantation (BMT). It has been postulated that the induction of acute GVHD requires the presence of Peyer's patches (PP). A new TNF-deficient strain has been developed that totally lack PP and displays the defects characteristic of TNF ablation but not lymphotoxin-associated defects characterized by lack of both PP and lymph nodes. To determine the necessity of PP in acute lethal GVHD induction, we transplanted myeloablated TNF knockout recipients with full MHC mismatched grafts. No differences in the survival or GVHD-associated histopathological lesions were observed between the recipients. We conclude that neither PP nor host-TNF- is required for the development of acute lethal GVHD in mice that receive myeloablative conditioning and allogeneic BMT.
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