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Blood, 15 November 2005, Vol. 106, No. 10, pp. 3646-3649. Prepublished online as a Blood First Edition Paper on August 11, 2005; DOI 10.1182/blood-2004-12-4603. This Article Full Text (PDF) Supplemental Figure All Versions of this Article: 2004-12-4603v1 106/10/3646    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Reyes, M. Articles by Chamberlain, J. S Search for Related Content PubMed PubMed Citation Articles by Reyes, M. Articles by Chamberlain, J. S Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 3, 2004 Accepted July 23, 2005 Donor origin of multipotent adult progenitor cells in radiation chimeras Morayma Reyes, Sheng Li, Jessica Foraker, En Kimura, and Jeffrey S Chamberlain* Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA; Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA; Department of Biochemistry and Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA; Muscular Dystrophy Cooperative Research Center, University of Washington School of Medicine, Seattle, WA, USA * Corresponding author; email: jsc5{at}u.washington.edu. Multipotent Adult Progenitor Cells (MAPC) are bone marrow derived stem cells that have extensive in vitro expansion capacity and can differentiate in vivo and in vitro into tissue cells of all three germinal layers: ectoderm, mesoderm, endoderm. The origin of MAPC within bone marrow is unknown. MAPC are believed to be derived from the bone marrow stroma compartment as they are isolated within the adherent cell component. Numerous studies of bone marrow chimeras in human and mouse point to a host origin of bone marrow stromal cells. Mesenchymal stem cells (MSC), which coexist with stromal cells, have also been proven to be of host origin post-allogeneic bone marrow transplantation in numerous studies. We report here that following syngeneic bone marrow transplants into lethally irradiated C57BL6 mice, MAPC are of donor origin. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Sun, C. O. Martinez, O. Ochoa, L. Ruiz-Willhite, J. R. Bonilla, V. E. Centonze, L. L. Waite, J. E. Michalek, L. M. McManus, and P. K. Shireman Bone marrow-derived cell regulation of skeletal muscle regeneration FASEB J, February 1, 2009; 23(2): 382 - 395. [Abstract] [Full Text] [PDF] M. Shi, J. Li, L. Liao, B. Chen, B. Li, L. Chen, H. Jia, and R. C. Zhao Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice Haematologica, July 1, 2007; 92(7): 897 - 904. [Abstract] [Full Text] [PDF] M. Serafini, S. J. Dylla, M. Oki, Y. Heremans, J. Tolar, Y. Jiang, S. M. Buckley, B. Pelacho, T. C. Burns, S. Frommer, et al. Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells J. Exp. Med., January 22, 2007; 204(1): 129 - 139. [Abstract] [Full Text] [PDF] X. Shi and D. J. Garry Muscle stem cells in development, regeneration, and disease. Genes & Dev., July 1, 2006; 20(13): 1692 - 1708. [Abstract] [Full Text] [PDF]

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