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Blood, 1 September 2005, Vol. 106, No. 5, pp. 1762-1769. Prepublished online as a Blood First Edition Paper on May 19, 2005; DOI 10.1182/blood-2004-12-4631. This Article Full Text (PDF) All Versions of this Article: 2004-12-4631v1 106/5/1762    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hoffmann, C. Articles by Horst, H.-A. Search for Related Content PubMed PubMed Citation Articles by Hoffmann, C. Articles by Horst, H.-A. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 8, 2004 Accepted April 10, 2005 AIDS-related B-cell lymphoma (ARL): Correlation of prognosis with differentiation profiles assessed by immunophenotyping Christian Hoffmann*, Markus Tiemann, Carsten Schrader, Dirk Janssen, Eva Wolf, Mathias Vierbuchen, Reza Parwaresch, Karen Ernestus, Andreas Plettenberg, Albrecht Stoehr, Gerd Fatkenheuer, Christoph Wyen, Mark Oette, and Heinz-August Horst II. Department of Medicine, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany Institute of Hematopathology and Lymphnode Registry, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany II. Department of Medicine, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany; Institute of Hematopathology and Lymphnode Registry, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany KIS-Curatorium for Immunodeficiency, Munich, Germany Hospital of St. Georg, Hamburg, Germany Institute of Pathology, University Clinic of Cologne, Cologne, Germany Institute for Interdisciplinary Infectiology (ifi), Hamburg, Germany Department of Internal Medicine, University Clinic of Cologne, Cologne, Germany University Clinic of Dusseldorf, Dusseldorf, Germany * Corresponding author; email: c.hoffmann{at}med2.uni-kiel.de. This study was undertaken to analyse the differentiation profiles assessed by immunophenotyping in AIDS-related lymphoma (ARL) and their relation to the clinical course. Paraffin embedded sections of 89 ARL cases during 1989-2004 were stained immunohistochemically with antibodies to CD3, CD10, CD20, CD38, CD138/Syn-1, MUM1/IRF4, BCL-2, BCL-6, LMP-1, and Ki-67. Expression of CD10 and CD20 were associated with better overall survival (OS, p=0.009 and p=0.04, respectively). Expression of CD20 was associated with longer disease-free survival (DFS, p=0.03), whereas expression of CD138/Syn-1 was associated with shorter DFS (p=0.03). OS and DFS were worse in patients with immunophenotypic profiles related to post-germinal center (GC) differentiation (BCL-6 and CD10 negative, MUM1/IRF4 and/or CD138/Syn-1 positive) when compared to GC differentiation (p=0.01). When controlled for age-adjusted International Prognostic Index (IPI), prior AIDS-defining illness (ADI) and year of ARL diagnosis, a post-GC differentiation remained significantly associated with poor OS and DFS. Expression of CD10 was associated with a preserved immunocompetence whereas CD20 was less frequent in patients developing ARL while on highly active antiretroviral therapy (p=0.04). In summary, lack of CD20 or CD10 expression and a post-germinal center signature are associated with a worse prognosis in ARL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Chadburn, A. Chiu, J. Y. Lee, X. Chen, E. Hyjek, A. H. Banham, A. Noy, L. D. Kaplan, J. A. Sparano, K. Bhatia, et al. Immunophenotypic Analysis of AIDS-Related Diffuse Large B-Cell Lymphoma and Clinical Implications in Patients From AIDS Malignancies Consortium Clinical Trials 010 and 034 J. Clin. Oncol., October 20, 2009; 27(30): 5039 - 5048. [Abstract] [Full Text] [PDF] F. Malavasi, S. Deaglio, A. Funaro, E. Ferrero, A. L. Horenstein, E. Ortolan, T. Vaisitti, and S. Aydin Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology Physiol Rev, July 1, 2008; 88(3): 841 - 886. [Abstract] [Full Text] [PDF]

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