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Blood, 1 May 2005, Vol. 105, No. 9, pp. 3746-3748. Prepublished online as a Blood First Edition Paper on January 6, 2005; DOI 10.1182/blood-2004-12-4692. This Article Full Text (PDF) All Versions of this Article: 2004-12-4692v1 105/9/3746    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mqadmi, A. Articles by Yazdanbakhsh, K. Search for Related Content PubMed PubMed Citation Articles by Mqadmi, A. Articles by Yazdanbakhsh, K. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 9, 2004 Accepted December 27, 2004 CD4+CD25+ regulatory T cells control induction of autoimmune hemolytic anemia Amina Mqadmi, Xiaoying Zheng, and Karina Yazdanbakhsh* Complement Biology, New York Blood Center, New York, NY, USA * Corresponding author; email: kyazdanbakhsh{at}nybloodcenter.org. Autoimmune hemolytic anemia (AIHA) is the result of increased destruction of red blood cells (RBCs) due to the production of autoantibodies and can be life-threatening. To study mechanisms that trigger AIHA, we used the Marshall-Clarke and Playfair model of murine AIHA, in which mice repeatedly immunized with rat RBCs develop erythrocyte autoantibodies as well as rat-specific alloantibodies. We analyzed the role of CD25+ T regulatory subsets in controlling AIHA in C57/Bl6 mice using antibody depletion studies. Treatment with anti-CD25 antibody, but not isotype control prior to immunization with rat RBCs increased the incidence of AIHA from 30% to 90%. Adoptive transfer of purified splenic population of CD4+CD25+, but not CD4+CD25- cells from immunized mice into naive recipients prevented the induction of autoantibody production. Altogether, our data establishes a critical role for CD4+CD25+ cells for control of AIHA which may help to establish therapeutic strategies for treatment of AIHA. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: W. Bao, J. Yu, S. Heck, and K. Yazdanbakhsh Regulatory T-cell status in red cell alloimmunized responder and nonresponder mice Blood, May 28, 2009; 113(22): 5624 - 5627. [Abstract] [Full Text] [PDF] K. K. Hoyer, W. F. Kuswanto, E. Gallo, and A. K. Abbas Distinct roles of helper T-cell subsets in a systemic autoimmune disease Blood, January 8, 2009; 113(2): 389 - 395. [Abstract] [Full Text] [PDF] I L Huibregtse, A U van Lent, and S J H van Deventer Immunopathogenesis of IBD: insufficient suppressor function in the gut? Gut, April 1, 2007; 56(4): 584 - 592. [Full Text] [PDF] K. N. Couper, D. G. Blount, J. B. de Souza, I. Suffia, Y. Belkaid, and E. M. Riley Incomplete Depletion and Rapid Regeneration of Foxp3+ Regulatory T Cells Following Anti-CD25 Treatment in Malaria-Infected Mice J. Immunol., April 1, 2007; 178(7): 4136 - 4146. [Abstract] [Full Text] [PDF] K. Yazdanbakhsh, X. Zheng, J. Yu, and S. Heck Prevention of Red Cell Alloimmunization by CD25 Regulatory T Cells. Blood (ASH Annual Meeting Abstracts), November 16, 2006; 108(11): 22 - 22. [Abstract] [PDF] H. W. Lim, P. Hillsamer, A. H. Banham, and C. H. Kim Cutting Edge: Direct Suppression of B Cells by CD4+CD25+ Regulatory T Cells J. Immunol., October 1, 2005; 175(7): 4180 - 4183. [Abstract] [Full Text] [PDF] M. L. Fields, B. D. Hondowicz, M. H. Metzgar, S. A. Nish, G. N. Wharton, C. C. Picca, A. J. Caton, and J. Erikson CD4+CD25+ Regulatory T Cells Inhibit the Maturation but Not the Initiation of an Autoantibody Response J. Immunol., October 1, 2005; 175(7): 4255 - 4264. [Abstract] [Full Text] [PDF]

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