SEARCH:   Advanced

Blood, 1 September 2005, Vol. 106, No. 5, pp. 1636-1643. Prepublished online as a Blood First Edition Paper on May 26, 2005; DOI 10.1182/blood-2004-12-4716. This Article Full Text (PDF) All Versions of this Article: 2004-12-4716v1 106/5/1636    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Huang, M.-T. Articles by Randi, A. M Search for Related Content PubMed PubMed Citation Articles by Huang, M.-T. Articles by Randi, A. M Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 13, 2004 Accepted May 7, 2005 Endothelial intercellular adhesion molecule (ICAM)-2 regulates angiogenesis Miao-Tzu Huang, Justin C Mason, Graeme M Birdsey, Valerie Amsellem, Nicole Gerwin, Dorian O Haskard, Anne J Ridley, and Anna M Randi* British Heart Foundation (BHF) Cardiovascular Sciences Unit,, Eric Bywaters Centre for Vascular Inflammation, Hammersmith Hospital, Imperial College, London, United Kingdom The Center for Blood Research, Harvard Medical School, Boston, MA, USA Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, United Kingdom * Corresponding author; email: a.randi{at}imperial.ac.uk. Endothelial junctions maintain endothelial integrity and vascular homeostasis. They modulate cell trafficking into tissues, mediate cell-cell contact and regulate endothelial survival and apoptosis. Junctional adhesion molecules such as VE-cadherin and CD31/PECAM mediate contact between adjacent endothelial cells and regulate leukocyte trans-migration and angiogenesis. The leukocyte adhesion molecule ICAM-2 is expressed at the endothelial junctions. In this study we demonstrate that endothelial ICAM-2 also mediates angiogenesis. Using ICAM-2-deficient mice and ICAM-2-deficient endothelial cells, we show that the lack of ICAM-2 expression results in impaired angiogenesis both in vitro and in vivo. We show that ICAM-2 supports homophilic interaction, and that this may be involved in tube formation. ICAM-2 deficient cells show defective in vitro migration, as well as increased apoptosis in response to serum deprivation, anti-Fas antibody or staurosporine. ICAM-2 signalling in human umbilical vein endothelial cells (HUVEC) was found to activate the small GTPase Rac, which is required for endothelial tube formation and migration. These data indicate that ICAM-2 may regulate angiogenesis via several mechanisms including survival, cell migration and Rac activation. Our findings identify a novel pathway regulating angiogenesis through ICAM-2 and a novel mechanism for Rac activation during angiogenesis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: ICAM-2: regulator of leukocyte migration and angiogenesis Dietmar Vestweber Blood 2005 106: 1510-1511. [Full Text] [PDF] This article has been cited by other articles: A. M. Randi and B. Bussolati Myeloid cell-induced angiogenesis: a sticky business Blood, June 25, 2009; 113(26): 6508 - 6510. [Full Text] [PDF] A. Woodfin, M.-B. Voisin, B. A. Imhof, E. Dejana, B. Engelhardt, and S. Nourshargh Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1 Blood, June 11, 2009; 113(24): 6246 - 6257. [Abstract] [Full Text] [PDF] G. M. Birdsey, N. H. Dryden, V. Amsellem, F. Gebhardt, K. Sahnan, D. O. Haskard, E. Dejana, J. C. Mason, and A. M. Randi Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin Blood, April 1, 2008; 111(7): 3498 - 3506. [Abstract] [Full Text] [PDF] S. M. Nauli, Y. Kawanabe, J. J. Kaminski, W. J. Pearce, D. E. Ingber, and J. Zhou Endothelial Cilia Are Fluid Shear Sensors That Regulate Calcium Signaling and Nitric Oxide Production Through Polycystin-1 Circulation, March 4, 2008; 117(9): 1161 - 1171. [Abstract] [Full Text] [PDF] M. A. Zayed, W. Yuan, T. M. Leisner, D. Chalothorn, A. W. McFadden, M. D. Schaller, M. E. Hartnett, J. E. Faber, and L. V. Parise CIB1 Regulates Endothelial Cells and Ischemia-Induced Pathological and Adaptive Angiogenesis Circ. Res., November 26, 2007; 101(11): 1185 - 1193. [Abstract] [Full Text] [PDF] J. D. van Buul, E. Kanters, and P. L. Hordijk Endothelial Signaling by Ig-Like Cell Adhesion Molecules Arterioscler Thromb Vasc Biol, September 1, 2007; 27(9): 1870 - 1876. [Abstract] [Full Text] [PDF] H. Caldas, J. R. Fangusaro, D. R. Boue, M. P. Holloway, and R. A. Altura Dissecting the role of endothelial SURVIVIN {Delta}Ex3 in angiogenesis Blood, February 15, 2007; 109(4): 1479 - 1489. [Abstract] [Full Text] [PDF] M.-T. Huang, K. Y. Larbi, C. Scheiermann, A. Woodfin, N. Gerwin, D. O. Haskard, and S. Nourshargh ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1-independent transmigration Blood, June 15, 2006; 107(12): 4721 - 4727. [Abstract] [Full Text] [PDF]

	Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020