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Blood, 15 June 2005, Vol. 105, No. 12, pp. 4553-4560. Prepublished online as a Blood First Edition Paper on February 22, 2005; DOI 10.1182/blood-2004-12-4750. This Article Full Text (PDF) All Versions of this Article: 2004-12-4750v1 105/12/4553    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Re, D. Articles by Diehl, V. Search for Related Content PubMed PubMed Citation Articles by Re, D. Articles by Diehl, V. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 14, 2004 Accepted February 11, 2005 From Hodgkin's disease to Hodgkin lymphoma: biological insights and therapeutic potential Daniel Re*, Roman K Thomas, Karolin Behringer, and Volker Diehl Department I of Internal Medicine, University of Cologne, Cologne, Germany; The Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; John Reed Laboratory, The Burnham Institute, La Jolla, CA, USA Department I of Internal Medicine, University of Cologne, Cologne, Germany; The Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA Department I of Internal Medicine, University of Cologne, Cologne, Germany Department I of Internal Medicine, University of Cologne, Cologne, Germany; The Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany * Corresponding author; email: dre{at}burnham.org. Reclassification of Hodgkin's disease as Hodgkin's Lymphoma (HL) represents a milestone in the lymphoma field awarding recent insights in the molecular biology of Hodgkin and Reed-Sternberg (H-RS) cells and their environment. This review summarizes antiapoptotic and proproliferative pathways involved in the pathogenesis of this disease with the ultimate goal of translating laboratory knowledge into clinical decision making. The focus is on potential targets and novel drugs, which are discussed in the context of the complex biology of HL. Considering that HL patients are more likely to die from acute and late toxicities than from HL itself, the introduction of targeted, biologically based therapies for HL patients with palliative and eventually curative intention might be justified. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. J. Salipante, M. E. Mealiffe, J. Wechsler, M. M. Krem, Y. Liu, S. Namkoong, G. Bhagat, T. Kirchhoff, K. Offit, H. Lynch, et al. Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells PNAS, September 1, 2009; 106(35): 14920 - 14925. [Abstract] [Full Text] [PDF] B. Boll, F. Eltaib, K. S. Reiners, B. von Tresckow, S. Tawadros, V. R. Simhadri, F. J. Burrows, K. Lundgren, H. P. Hansen, A. Engert, et al. Heat Shock Protein 90 Inhibitor BIIB021 (CNF2024) Depletes NF-{kappa}B and Sensitizes Hodgkin's Lymphoma Cells for Natural Killer Cell-Mediated Cytotoxicity Clin. Cancer Res., August 15, 2009; 15(16): 5108 - 5116. [Abstract] [Full Text] [PDF] K.-C. Chang, Y. Chang, D. Jones, and I.-J. Su Aberrant Expression of Cyclin A Correlates With Morphogenesis of Reed-Sternberg Cells in Hodgkin Lymphoma Am J Clin Pathol, July 1, 2009; 132(1): 50 - 59. [Abstract] [Full Text] [PDF] D. Buglio, G. V. Georgakis, S. Hanabuchi, K. Arima, N. M. Khaskhely, Y.-J. Liu, and A. 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Romagosa, et al. Tumor microenvironment and mitotic checkpoint are key factors in the outcome of classic Hodgkin lymphoma Blood, July 15, 2006; 108(2): 662 - 668. [Abstract] [Full Text] [PDF]

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