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Blood, 15 September 2005, Vol. 106, No. 6, pp. 2033-2041. Prepublished online as a Blood First Edition Paper on June 7, 2005; DOI 10.1182/blood-2004-12-4831. This Article Full Text (PDF) All Versions of this Article: 2004-12-4831v1 106/6/2033    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Guo, Z. Articles by Cao, X. Search for Related Content PubMed PubMed Citation Articles by Guo, Z. Articles by Cao, X. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 20, 2004 Accepted May 18, 2005 Fas signal links innate and adaptive immunity by promoting dendritic cell secretion of CC and CXC chemokines Zhenhong Guo, Minghui Zhang, Hua Tang, and Xuetao Cao* Institute of Immunology, Second Military Medical University, Shanghai, China Institute of Immunology, School of Medicine, Tsinghua Universtiy, Beijing, China Institute of Immunology, Zhejiang University, Hangzhou, China Institute of Immunology, Second Military Medical University, Shanghai, China; Institute of Immunology, School of Medicine, Tsinghua Universtiy, Beijing, China; Institute of Immunology, Zhejiang University, Hangzhou, China * Corresponding author; email: caoxt{at}public3.sta.net.cn. Dendritic cells (DC) and chemokines are important in linking innate and adaptive immunity. We previously reported that Fas ligation induced IL-1beta-dependent maturation and IL-1beta-independent survival of DC, with ERK and NF-kappaB signaling pathways involved respectively. We describe here that Fas ligation induced DC to rapidly produce both CXC and CC chemokines, including MIP-2, MIP-1alpha, MIP-1beta, MCP-1, RANTES and TARC, resulting in enhanced chemoattraction of neutrophils and T cells by Fas-ligated DC in vivo or by its supernatant in vitro. These chemokines work synergistically in chemoattraction of neutrophils and T cells with MIP-2 more important for neutrophils, MIP-1alpha and TARC more important for T cells. Moreover, Fas-ligated DC increased endocytosis by neutrophils and activation and proliferation of antigen-specific naive T cells. Fas ligation-induced DC secretion of chemokines involves Ras/Raf/MEK/ERK activation and is ERK-, but not NF-kappaB, dependent. Activation of caspases including caspase 1, but not IL-1 autocrine action, is involved in this process. These data indicate that Fas signaling provides a key link between innate response and adaptive immunity by promoting DC chemokine production. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. Zhang, Q. Liu, M. Zhang, Y. Yu, X. Liu, and X. Cao Fas Signal Promotes Lung Cancer Growth by Recruiting Myeloid-Derived Suppressor Cells via Cancer Cell-Derived PGE2 J. Immunol., March 15, 2009; 182(6): 3801 - 3808. [Abstract] [Full Text] [PDF] B. Rethi, N. Vivar, S. Sammicheli, C. Fluur, N. Ruffin, A. Atlas, E. Rajnavolgyi, and F. Chiodi Priming of T cells to Fas-mediated proliferative signals by interleukin-7 Blood, August 15, 2008; 112(4): 1195 - 1204. [Abstract] [Full Text] [PDF] G. Plitas, B. M. Burt, H. M. Nguyen, Z. M. Bamboat, and R. P. 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