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Blood, 15 July 2005, Vol. 106, No. 2, pp. 746-748. Prepublished online as a Blood First Edition Paper on March 29, 2005; DOI 10.1182/blood-2004-12-4855. This Article Full Text (PDF) All Versions of this Article: 2004-12-4855v1 106/2/746    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Detivaud, L. Articles by Loreal, O. Search for Related Content PubMed PubMed Citation Articles by Detivaud, L. Articles by Loreal, O. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 22, 2004 Accepted March 18, 2005 Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels and hepatic function Lenaick Detivaud, Elizabeta Nemeth, Karim Boudjema, Bruno Turlin, Marie-Berengere Troadec, Patricia Leroyer, Martine Ropert, Sylvie Jacquelinet, Brice Courselaud, Tomas Ganz, Pierre Brissot, and Olivier Loreal* INSERM, U522; Universite de Rennes 1, Rennes, France Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA INSERM, U522; Universite de Rennes 1, Rennes, France; Department of Visceral Surgery, University Hospital Pontchaillou, Rennes, France INSERM, U522; Universite de Rennes 1, Rennes, France; Department of Pathology, University Hospital Pontchaillou, Rennes, France Laboratory of General Biochemistry and Enzymology, University Hospital Pontchaillou, Rennes, France Liver Disease Department, University Hospital Pontchaillou, Rennes, France INSERM, U522; Universite de Rennes 1, Rennes, France; Liver Disease Department, University Hospital Pontchaillou, Rennes, France * Corresponding author; email: olivier.loreal{at}rennes.inserm.fr. Hepcidin, a key regulator of iron metabolism, is synthesized by the liver. Hepcidin binds to the iron exporter ferroportin to regulate the release of iron into plasma from macrophages, hepatocytes and enterocytes. We analyzed liver samples from patients undergoing hepatic surgery for cancer or receiving liver transplants, and analyzed correlations between clinical parameters, liver hepcidin mRNA and urinary hepcidin concentrations. Despite the many potential confounding influences, urinary hepcidin concentrations significantly correlated with hepatic hepcidin mRNA concentrations, indicating that hepcidin quantification in urine is a valid approach to evaluate hepcidin expression. Moreover, we found in humans that hepcidin levels correlated with hepatic iron stores and hemoglobin level, and may also be affected by hepatic dysfunction. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. Young and J. Zaritsky Hepcidin for Clinicians Clin. J. Am. Soc. Nephrol., August 1, 2009; 4(8): 1384 - 1387. [Abstract] [Full Text] [PDF] D. D. Harrison-Findik, E. Klein, J. Evans, and J. Gollan Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-{alpha} signaling Am J Physiol Gastrointest Liver Physiol, January 1, 2009; 296(1): G112 - G118. [Abstract] [Full Text] [PDF] E. H.J.M. Kemna, H. Tjalsma, H. L. Willems, and D. W. Swinkels Hepcidin: from discovery to differential diagnosis Haematologica, January 1, 2008; 93(1): 90 - 97. [Abstract] [Full Text] [PDF] E. H.J.M. Kemna, H. Tjalsma, V. N. Podust, and D. W. Swinkels Mass Spectrometry-Based Hepcidin Measurements in Serum and Urine: Analytical Aspects and Clinical Implications Clin. Chem., April 1, 2007; 53(4): 620 - 628. [Abstract] [Full Text] [PDF] T. Ganz Molecular Control of Iron Transport J. Am. Soc. Nephrol., February 1, 2007; 18(2): 394 - 400. [Abstract] [Full Text] [PDF] K. B Hadley, L. K Johnson, and J. R Hunt Iron absorption by healthy women is not associated with either serum or urinary prohepcidin Am. J. Clinical Nutrition, July 1, 2006; 84(1): 150 - 155. [Abstract] [Full Text] [PDF] D. W. Swinkels, M. C.H. Janssen, J. Bergmans, and J. J.M. Marx Hereditary Hemochromatosis: Genetic Complexity and New Diagnostic Approaches Clin. Chem., June 1, 2006; 52(6): 950 - 968. [Abstract] [Full Text] [PDF] S. J. Wilkins, D. M. Frazer, K. N. Millard, G. D. McLaren, and G. J. Anderson Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expression Blood, February 15, 2006; 107(4): 1659 - 1664. [Abstract] [Full Text] [PDF]

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