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Blood, 1 August 2005, Vol. 106, No. 3, pp. 886-892. Prepublished online as a Blood First Edition Paper on April 21, 2005; DOI 10.1182/blood-2004-12-4881. This Article Full Text (PDF) All Versions of this Article: 2004-12-4881v1 106/3/886    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Harman, B. C Articles by Anderson, G. Search for Related Content PubMed PubMed Citation Articles by Harman, B. C Articles by Anderson, G. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 27, 2004 Accepted April 10, 2005 T/B lineage choice occurs prior to intrathymic notch signalling Benjamin C Harman, William E Jenkinson, Sonia M Parnell, Simona W Rossi, Eric J Jenkinson, and Graham Anderson* Department of Anatomy, MRC Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham, United Kingdom * Corresponding author; email: g.anderson{at}bham.ac.uk. Commitment of haemopoietic progenitors to the T-cell lineage is a crucial requirement for T-cell development, yet the timing and developmental cues regulating this process remain controversial. Here we have devised a technique to analyse the T cell/B cell lineage potential of precursors that have been recruited to the fetal mouse thymus but which have yet to contact the thymic epithelial microenvironment. We show that lymphoid progenitors arriving at the thymus are not bipotent T/B precursors, and provide evidence that intrathymic Notch signalling is not the mechanism determining T/B lineage choice in migrant precursors. Rather, we provide evidence that Notch signalling influences T/B lineage choice in lymphoid precursors through interactions with defined stromal components within the fetal liver. Collectively, our data redefines our understanding of the role and timing of Notch signalling in relation to lineage choices in lymphoid precursors. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Extrathymic commitment to T-cell lineage Louise M. C. Webb Blood 2005 106: 770-771. [Full Text] [PDF] This article has been cited by other articles: S. Zuklys, J. Gill, M. P. Keller, M. Hauri-Hohl, S. Zhanybekova, G. Balciunaite, K.-J. Na, L. T. Jeker, K. Hafen, N. Tsukamoto, et al. Stabilized {beta}-Catenin in Thymic Epithelial Cells Blocks Thymus Development and Function J. Immunol., March 1, 2009; 182(5): 2997 - 3007. [Abstract] [Full Text] [PDF] K. Hozumi, C. Mailhos, N. Negishi, K.-i. Hirano, T. Yahata, K. Ando, S. Zuklys, G. A. Hollander, D. T. Shima, and S. Habu Delta-like 4 is indispensable in thymic environment specific for T cell development J. Exp. Med., October 27, 2008; 205(11): 2507 - 2513. [Abstract] [Full Text] [PDF] A. White, D. Carragher, S. Parnell, A. Msaki, N. Perkins, P. Lane, E. Jenkinson, G. Anderson, and J. H. Caamano Lymphotoxin a-dependent and -independent signals regulate stromal organizer cell homeostasis during lymph node organogenesis Blood, September 15, 2007; 110(6): 1950 - 1959. [Abstract] [Full Text] [PDF] M. Itoi, N. Tsukamoto, H. Yoshida, and T. Amagai Mesenchymal cells are required for functional development of thymic epithelial cells Int. Immunol., August 1, 2007; 19(8): 953 - 964. [Abstract] [Full Text] [PDF] W. E. Jenkinson, S. W. Rossi, S. M. Parnell, E. J. Jenkinson, and G. Anderson PDGFR{alpha}-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches Blood, February 1, 2007; 109(3): 954 - 960. [Abstract] [Full Text] [PDF] K. Heinzel, C. Benz, V. C. Martins, I. D. Haidl, and C. C. Bleul Bone Marrow-Derived Hemopoietic Precursors Commit to the T Cell Lineage Only after Arrival in the Thymic Microenvironment J. Immunol., January 15, 2007; 178(2): 858 - 868. [Abstract] [Full Text] [PDF] S. S. Perry, R. S. Welner, T. Kouro, P. W. Kincade, and X.-H. Sun Primitive lymphoid progenitors in bone marrow with T lineage reconstituting potential. J. Immunol., September 1, 2006; 177(5): 2880 - 2887. [Abstract] [Full Text] [PDF] T. Ikawa, H. Kawamoto, A. W. Goldrath, and C. Murre E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment J. Exp. Med., May 15, 2006; 203(5): 1329 - 1342. [Abstract] [Full Text] [PDF] T. Yokota, J. Huang, M. Tavian, Y. Nagai, J. Hirose, J.-C. Zuniga-Pflucker, B. Peault, and P. W. Kincade Tracing the first waves of lymphopoiesis in mice Development, May 15, 2006; 133(10): 2041 - 2051. [Abstract] [Full Text] [PDF] I. Maillard, B. A. Schwarz, A. Sambandam, T. Fang, O. Shestova, L. Xu, A. Bhandoola, and W. S. Pear Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation Blood, May 1, 2006; 107(9): 3511 - 3519. [Abstract] [Full Text] [PDF] M. Lu, R. Tayu, T. Ikawa, K. Masuda, I. Matsumoto, H. Mugishima, H. Kawamoto, and Y. Katsura The Earliest Thymic Progenitors in Adults Are Restricted to T, NK, and Dendritic Cell Lineage and Have a Potential to Form More Diverse TCR{beta} Chains than Fetal Progenitors J. Immunol., November 1, 2005; 175(9): 5848 - 5856. [Abstract] [Full Text] [PDF]

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