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Blood, 1 August 2005, Vol. 106, No. 3, pp. 1037-1041.
Prepublished online as a Blood First Edition Paper on April 21, 2005; DOI 10.1182/blood-2005-01-0004.
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Submitted January 13, 2005
Accepted March 31, 2005
Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21)
Kun-Huei Yeh, Sung-Hsin Kuo, Li-Tzong Chen, Tsui-Lien Mao, Shin-Lian Doong, Ming-Shiang Wu, Hui-Chen Hsu, Yi-Shin Tzeng, Chi-Long Chen, Jaw-Town Lin, and Ann-Lii Cheng*
Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Cancer Research Center, National Taiwan University College of Medicine, Taipei, Taiwan
Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Cancer Research Center, National Taiwan University College of Medicine, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
Division of Cancer Research, National Health Research Institutes, Taipei, Taiwan; Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Graduate Institute of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Cancer Research Center, National Taiwan University College of Medicine, Taipei, Taiwan
Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
* Corresponding author; email: andrew{at}ha.mc.ntu.edu.tw.
T(11;18)(q21;q21) is a specific marker for Helicobacter pylori (H pylori)-independent status of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, there are currently no reliable markers to predict tumor response to H pylori eradication for cases without t(11;18)(q21;q21). Nuclear expression of BCL10 and NF-kB was recently found to be closely associated with H pylori-independent status of the high-grade counterpart of gastric MALT lymphoma, which usually lacks t(11;18)(q21;q21). This study examined whether these two markers can also predict H pylori-independent status of low-grade gastric MALT lymphomas without t(11;18)(q21;q21). Sixty patients who underwent successful H pylori eradication for low-grade gastric MALT lymphomas were included. Forty-seven (78.3%) patients were negative for t(11;18)(q21;q21); among them, 36 (76.6%) were H pylori-dependent and 11 (23.4%) were H pylori-independent . Nuclear expression of BCL10 was significantly higher in H pylori-independent than in H pylori-dependent tumors (8 of 11 [72.7%] vs 3 of 36 [8.3%]; P < .001). Nuclear expression of NF- B was also significantly higher in H pylori-independent than in H pylori-dependent tumors (7 of 11 [63.6%] vs 3 of 36 [8.3%]; P < .001). Further, nuclear translocation of BCL10 and NF-B was observed in 12 of the 13 cases with t(11;18)(q21;q21); and all these 12 cases were H pylori-independent. In summary, nuclear expression of BCL10 or NF-B is predictive of H pylori-independent status of low-grade gastric MALT lymphoma with or without t(11;18)(q21;q21).
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