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Blood, 15 January 2006, Vol. 107, No. 2, pp. 806-812. Prepublished online as a Blood First Edition Paper on October 4, 2005; DOI 10.1182/blood-2005-01-0154. This Article Full Text (PDF) Supplemental Figure All Versions of this Article: 2005-01-0154v1 107/2/806    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hatterer, E. Articles by Nataf, S. Search for Related Content PubMed PubMed Citation Articles by Hatterer, E. Articles by Nataf, S. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 12, 2005 Accepted September 9, 2005 How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes Eric Hatterer, Nathalie Davoust, Marianne Didier-Bazes, Carine Vuaillat, Christophe Malcus, Marie-Francoise Belin, and Serge Nataf* INSERM U433, IFR 19, Faculte de Medecine Laennec, Universite Claude Bernard Lyon 1, Lyon, France * Corresponding author; email: nataf{at}lyon.inserm.fr. The lack of draining lymphatic vessels in the central nervous system (CNS) contributes to the so-called "CNS immune privilege". However, despite such a unique anatomical feature, dendritic cells (DCs) are able to migrate from the CNS to cervical lymph nodes through a yet unknown pathway. In this paper, labeled bone marrow-derived myeloid DCs were injected stereotaxically into the cerebrospinal fluid (CSF) or brain parenchyma of normal rats. We found that DCs injected within brain parenchyma migrate little from their site of injection and do not reach cervical lymph nodes. In contrast, intra-CSF injected DCs either reach cervical lymph nodes or, for a minority of them, infiltrate the subventricular zone, where neural stem cells reside. Surprisingly, DCs that reach cervical lymph nodes preferentially target B-cell follicles rather than T-cell rich areas. This report sheds a new light on the specific role exerted by CSF-infiltrating DCs in the control of CNS-targeted immune responses. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. He, Y. Yin, T. A. Luster, L. Watkins, and P. E. Thorpe Antiphosphatidylserine Antibody Combined with Irradiation Damages Tumor Blood Vessels and Induces Tumor Immunity in a Rat Model of Glioblastoma Clin. Cancer Res., November 15, 2009; 15(22): 6871 - 6880. [Abstract] [Full Text] [PDF] K. J. McCann, M. Ashton-Key, K. Smith, F. K. Stevenson, and C. H. Ottensmeier Primary central nervous system lymphoma: tumor-related clones exist in the blood and bone marrow with evidence for separate development Blood, May 7, 2009; 113(19): 4677 - 4680. [Abstract] [Full Text] [PDF] S. Hochmeister, M. Zeitelhofer, J. Bauer, E.-M. Nicolussi, M.-T. Fischer, B. Heinke, E. Selzer, H. Lassmann, and M. Bradl After Injection into the Striatum, in Vitro-Differentiated Microglia- and Bone Marrow-Derived Dendritic Cells Can Leave the Central Nervous System via the Blood Stream Am. J. Pathol., December 1, 2008; 173(6): 1669 - 1681. [Abstract] [Full Text] [PDF] R. A. O'Connor, K. H. Malpass, and S. M. Anderton The Inflamed Central Nervous System Drives the Activation and Rapid Proliferation of Foxp3+ Regulatory T Cells J. Immunol., July 15, 2007; 179(2): 958 - 966. [Abstract] [Full Text] [PDF] L. Walter and M. L. Albert Cutting Edge: Cross-Presented Intracranial Antigen Primes CD8+ T Cells J. Immunol., May 15, 2007; 178(10): 6038 - 6042. [Abstract] [Full Text] [PDF] H. Xu, R. Dawson, J. V. Forrester, and J. Liversidge Identification of Novel Dendritic Cell Populations in Normal Mouse Retina Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1701 - 1710. [Abstract] [Full Text] [PDF] J. Goldmann, E. Kwidzinski, C. Brandt, J. Mahlo, D. Richter, and I. Bechmann T cells traffic from brain to cervical lymph nodes via the cribroid plate and the nasal mucosa J. Leukoc. Biol., October 1, 2006; 80(4): 797 - 801. [Abstract] [Full Text] [PDF] N. L. Monson, M. K. Racke, and E. M. Frohman Characterizing the Mechanisms and Progression in Multiple Sclerosis: Evidence and New Hypotheses for Future Directions--Reply Arch Neurol, May 1, 2006; 63(5): 787 - 788. [Full Text] [PDF] J. F. Curtin, G. D. King, C. Barcia, C. Liu, F. X. Hubert, C. Guillonneau, R. Josien, I. Anegon, P. R. Lowenstein, and M. G. Castro Fms-Like Tyrosine Kinase 3 Ligand Recruits Plasmacytoid Dendritic Cells to the Brain J. Immunol., March 15, 2006; 176(6): 3566 - 3577. [Abstract] [Full Text] [PDF]

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