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Blood, 15 August 2005, Vol. 106, No. 4, pp. 1154-1163. Prepublished online as a Blood First Edition Paper on May 3, 2005; DOI 10.1182/blood-2005-01-0178. This Article Full Text (PDF) Erratum (v106,p2243) All Versions of this Article: 2005-01-0178v1 106/4/1154    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tallman, M. S Articles by Rowe, J. M Search for Related Content PubMed PubMed Citation Articles by Tallman, M. S Articles by Rowe, J. M Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 13, 2005 Accepted March 28, 2005 Drug therapy of acute myeloid leukemia Martin S Tallman*, D G Gilliland, and Jacob M Rowe Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, USA Division of Hematology/Oncology, Brigham and Women's Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA Department of Hematology and Bone Marrow Transplantation, Rambam Medical Center, Technion Israel Institute of Technology, Haifa, Israel * Corresponding author; email: m-tallman{at}northwestern.edu. While improvement in outcomes has occurred in younger adults with AML during the last four decades, progress in older adults has been much less conspicuous, if at all. Approximately 50-75% of adults with AML achieve complete remission (CR) with cytarabine and an anthracycline such as daunorubicin or idarubicin or the anthracenedione mitoxantrone. However, only approximately 20-30% of the patients enjoy long-term disease-survival. Various postremission strategies have been explored to eliminate minimal residual disease. The optimal dose, schedule and number of cycles of postremission chemotherapy for most patients are not known. A variety of prognostic factors can predict outcome, and include the karyotype of the leukemic cells, the presence of transmembrane transporter proteins which extrude certain chemotherapy agents from the cell and confer multidrug resistance and mutations in or over expressions of specific genes such as WT1, C/EBP[alpha], Bax, and Bcl-2/Bax ratio, BAALC, EVI1, KIT and Flt 3. Most recently, insights into the molecular pathogenesis of AML have led to the development of more specific targeted agents and have ushered in an exciting new era of antileukemia therapy. Such agents include: the immunoconjugate gemtuzumab ozogamicin, multidrug resistance inhibitors, farnesyl, transferase inhibitors, histone deacetylase and proteosome inhibitors, antiangiogenesis agents, Flt 3 inhibitors and apoptosis inhibitors. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Cavelier, C. Didier, N. Prade, V. Mansat-De Mas, S. Manenti, C. Recher, C. Demur, and B. Ducommun Constitutive Activation of the DNA Damage Signaling Pathway in Acute Myeloid Leukemia with Complex Karyotype: Potential Importance for Checkpoint Targeting Therapy Cancer Res., November 15, 2009; 69(22): 8652 - 8661. [Abstract] [Full Text] [PDF] S. W. Lane, D. T. Scadden, and D. G. 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