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Blood, 15 December 2005, Vol. 106, No. 13, pp. 4184-4190. Prepublished online as a Blood First Edition Paper on September 1, 2005; DOI 10.1182/blood-2005-01-0226. This Article Full Text (PDF) Supplemental Figure All Versions of this Article: 2005-01-0226v1 106/13/4184    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Religa, P. Articles by Cao, Y. Search for Related Content PubMed PubMed Citation Articles by Religa, P. Articles by Cao, Y. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 18, 2005 Accepted August 15, 2005 Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vessels Piotr Religa*, Renhai Cao, Meit Bjorndahl, Zhongjun Zhou, Zhenping Zhu, and Yihai Cao Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden Department of Biochemistry, Faculty of Medicine, Laboratory Block L3-78, University of Hong Kong, Pokfulam, Hong Kong ImClone Systems Incorporated, New York, NY, USA * Corresponding author; email: piotr.religa{at}mtc.ki.se. Bone marrow (BM)-derived circulating endothelial precursor cells (CEPCs) have been reported to incorporate into newly formed blood vessels under physiological and pathological conditions. However, it is unknown if CEPCs contribute to lymphangiogenesis. Here we show that in a corneal lymphangiogenesis model of irradiated mice reconstituted with enhanced green fluorescent protein (EGFP) positive donor bone marrow cells, CEPCs are present in the newly formed lymphatic vessels. Depletion of bone marrow cells by irradiation remarkably suppressed lymphangiogenesis in corneas implanted with FGF-2. Further, transplantation of isolated EGFP+/VEGFR-3+- or EGFP+/VEGFR-2+-cell populations resulted in incorporation of EGFP+ cells into the newly formed lymphatic vessels. EGFP+/CEPCs were also present in peritumoral lymphatic vessels of a fibrosarcoma. These data suggest that BM-derived CEPCs may play a role in 'lymphvasculogenesis'. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. K. Horst, T. Bickert, N. Brewig, P. Ludewig, N. van Rooijen, U. Schumacher, N. Beauchemin, W. D. Ito, B. Fleischer, C. Wagener, et al. CEACAM1+ myeloid cells control angiogenesis in inflammation Blood, June 25, 2009; 113(26): 6726 - 6736. [Abstract] [Full Text] [PDF] K. Bogos, F. Renyi-Vamos, J. Dobos, I. Kenessey, J. Tovari, J. Timar, J. Strausz, G. Ostoros, W. Klepetko, H. J. Ankersmit, et al. High VEGFR-3-positive Circulating Lymphatic/Vascular Endothelial Progenitor Cell Level Is Associated with Poor Prognosis in Human Small Cell Lung Cancer Clin. Cancer Res., March 1, 2009; 15(5): 1741 - 1746. [Abstract] [Full Text] [PDF] C. Conrad, H. Niess, R. Huss, S. Huber, I. von Luettichau, P. J. Nelson, H. C. Ott, K.-W. Jauch, and C. J. Bruns Multipotent Mesenchymal Stem Cells Acquire a Lymphendothelial Phenotype and Enhance Lymphatic Regeneration In Vivo Circulation, January 20, 2009; 119(2): 281 - 289. [Abstract] [Full Text] [PDF] H. Ichise, T. Ichise, O. Ohtani, and N. Yoshida Phospholipase C{gamma}2 is necessary for separation of blood and lymphatic vasculature in mice Development, January 15, 2009; 136(2): 191 - 195. [Abstract] [Full Text] [PDF] R. S. Srinivasan, M. E. Dillard, O. V. Lagutin, F.-J. Lin, S. Tsai, M.-J. Tsai, I. M. Samokhvalov, and G. Oliver Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature Genes & Dev., October 1, 2007; 21(19): 2422 - 2432. [Abstract] [Full Text] [PDF]

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