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Blood, 15 April 2006, Vol. 107, No. 8, pp. 3235-3242. Prepublished online as a Blood First Edition Paper on December 15, 2005; DOI 10.1182/blood-2005-01-0256. This Article Full Text (PDF) All Versions of this Article: 2005-01-0256v1 107/8/3235    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bischof, D. Articles by Bram, R. J Search for Related Content PubMed PubMed Citation Articles by Bischof, D. Articles by Bram, R. J Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 21, 2005 Accepted December 5, 2005 Selective activation of TACI by syndecan-2 Daniela Bischof, Sherine F Elsawa, George Mantchev, Juhan Yoon, Grace E Michels, Allan Nilson, Shari Sutor, Jeffrey L Platt, Stephen M Ansell, Gotz von Bulow, and Richard J Bram* Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Urology, Indiana University School of Medicine, Indianapolis, IN, USA Department of Hematology, Mayo Medical School, Mayo Clinic, Rochester, MN, USA Department of Pediatric and Adolescent Medicine, Mayo Medical School, Mayo Clinic, Rochester, MN, USA Department of Immunology, Mayo Medical School, Mayo Clinic, Rochester, MN, USA Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA Department of Immunology, Mayo Medical School, Mayo Clinic, Rochester, MN, USA; Department of Transplantation, Mayo Medical School, Mayo Clinic, Rochester, MN, USA Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA; Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN, USA Department of Pediatric and Adolescent Medicine, Mayo Medical School, Mayo Clinic, Rochester, MN, USA; Department of Immunology, Mayo Medical School, Mayo Clinic, Rochester, MN, USA * Corresponding author; email: richard.bram{at}mayo.edu. B lymphocyte homeostasis and function are regulated by complementary actions of the TNFR family members TACI, BCMA, and BAFF-R, which are expressed by mature B cells. How these receptors are differentially activated is not entirely understood, since the primary ligand BAFF binds to all three. We searched for alternative ligands for TACI using recombinant TACI-Fc fusion protein as a probe, and identified syndecan-2 as a new binding partner. TACI binding appears to require heparan sulfate post-translational modifications of syndecan-2, because free heparin or pretreatment with heparitinase blocked the interaction. Syndecan-2 bound TACI but bound neither BAFF-R nor BCMA. Transfected cells expressing syndecan-2 activated signaling through TACI, as indicated by an NFAT-specific reporter. Syndecan-1 and syndecan-4 were also able induce TACI signaling in a similar manner. This is the first identification of ligands that selectively activate TACI without simultaneously triggering BCMA or BAFF-R. This finding may help explain the alternative outcomes of signaling from this family of receptors in B cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Bossen, T. G. Cachero, A. Tardivel, K. Ingold, L. Willen, M. Dobles, M. L. Scott, A. Maquelin, E. Belnoue, C.-A. Siegrist, et al. TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts Blood, February 1, 2008; 111(3): 1004 - 1012. [Abstract] [Full Text] [PDF] J. R. Darce, B. K. Arendt, X. Wu, and D. F. Jelinek Regulated Expression of BAFF-Binding Receptors during Human B Cell Differentiation J. Immunol., December 1, 2007; 179(11): 7276 - 7286. [Abstract] [Full Text] [PDF] G. T. Mantchev, C. S. Cortesao, M. Rebrovich, M. Cascalho, and R. J. 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