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Blood, 15 September 2005, Vol. 106, No. 6, pp. 2091-2098. Prepublished online as a Blood First Edition Paper on June 9, 2005; DOI 10.1182/blood-2005-02-0449. This Article Full Text (PDF) All Versions of this Article: 2005-02-0449v1 106/6/2091    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by van Leeuwen, E. M Articles by van Lier, R. A Search for Related Content PubMed PubMed Citation Articles by van Leeuwen, E. M Articles by van Lier, R. A Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 2, 2005 Accepted May 22, 2005 IL-7 receptor -chain expression discriminates functional subsets of virus-specific human CD8+ T cells Ester M van Leeuwen*, Godelieve J de Bree, Ester B Remmerswaal, Si-La Yong, Kiki Tesselaar, Ineke J ten Berge, and Rene A van Lier Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands; Department of Internal Medicine, Divisions of Nephrology and Clinical Immunology &Rheumatology, Academic Medical Center, Amsterdam, The Netherlands Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands; Department of Pulmonology, Academic Medical Center, Amsterdam, The Netherlands Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands Department of Clinical Viro-Immunology, Sanquin Research at CLB, Amsterdam, The Netherlands Department of Internal Medicine, Divisions of Nephrology and Clinical Immunology &Rheumatology, Academic Medical Center, Amsterdam, The Netherlands * Corresponding author; email: e.m.vanleeuwen{at}amc.uva.nl. Virus-specific CD8+ T cells emerge after infection with herpesviruses and maintain latency to these persisting pathogens. It has been demonstrated that murine memory CD8+ T cell precursors specific for acute lymphocytic choriomeningitis virus express IL-7R and IL-7 is involved in maintaining memory populations after clearance of antigen. To investigate whether human CD8+ T cells reactive towards persisting viruses are maintained similarly, we analyzed IL-7R expression and function on these virus-specific cells. During primary infection all cytomegalovirus (CMV)-specific CD8+ T cells and most Epstein-Barr virus (EBV)-specific CD8+ T cells lacked IL-7R expression. Only some virus-specific T cells expressed IL-7R late after viral replication became undetectable. CD8+ T cells specific for cleared viruses, influenza (FLU) and respiratory syncytial virus (RSV), all expressed IL-7R. Remarkably, the percentage IL-7R- CMV-specific T cells correlated with the height of viral replication in the acute phase. Virus-specific IL-7R+ cells proliferated vigorously in response to IL-7, IL-15 or peptide, whereas IL-7R- cells required both peptide and helper-cell activation or IL-2 or IL-15 for optimal expansion. Our data suggest that although IL-7 is essential for the maintenance of memory cells in the absence of antigen, CD8+ T cells specific for latent viruses need T cell receptor activation plus helper factors to persist. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Sauce, M. Larsen, R. J. M. Abbott, A. D. Hislop, A. M. Leese, N. Khan, L. Papagno, G. J. Freeman, and A. B. Rickinson Upregulation of Interleukin 7 Receptor Alpha and Programmed Death 1 Marks an Epitope-Specific CD8+ T-Cell Response That Disappears following Primary Epstein-Barr Virus Infection J. 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