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Blood, 1 August 2005, Vol. 106, No. 3, pp. 879-885. Prepublished online as a Blood First Edition Paper on April 14, 2005; DOI 10.1182/blood-2005-02-0456. This Article Full Text (PDF) All Versions of this Article: 2005-02-0456v1 106/3/879    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Maeda, K. Articles by Coggeshall, K M Search for Related Content PubMed PubMed Citation Articles by Maeda, K. Articles by Coggeshall, K M Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 2, 2005 Accepted April 5, 2005 IL-6 blocks a discrete early step in lymphopoiesis Kazuhiko Maeda, Yoshihiro Baba, Yoshinori Nagai, Kozo Miyazaki, Alexander Malykhin, Koji Nakamura, Paul W Kincade, Nobuo Sakaguchi, and K M Coggeshall* Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA * Corresponding author; email: coggeshallm{at}omrf.ouhsc.edu. Animals lacking Src homology 2 domain-containing inositol 5-phosphatase (SHIP) display a reduction in lymphopoiesis and a corresponding enhancement of myelopoiesis. These effects are mediated at least in part by elevated IL-6. Here, we show the lymphopoiesis block in SHIP-/- mice is due to suppression of the lymphoid lineage choice by uncommitted progenitors. The suppression can be reproduced in vitro with recombinant IL-6, and IL-6 acts directly on hematopoietic progenitors. The block is partially overcome in SHIP-/-IL-6-/- double-deficient animals. IL-6 does not suppress but actually enhances proliferation of lymphoid-committed progenitors, indicating the IL-6 target cells are hematopoietic stem cells or multipotent progenitors. The findings suggest a mechanism for the lymphopenia that accompanies pro-inflammatory diseases. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Maeda, A. Malykhin, B. N. Teague-Weber, X.-H. Sun, A. D. Farris, and K. M. Coggeshall Interleukin-6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosus-prone B6.Sle1.Yaa animals Blood, May 7, 2009; 113(19): 4534 - 4540. [Abstract] [Full Text] [PDF] B. L. Esplin, R. S. Welner, Q. Zhang, L. A. Borghesi, and P. W. Kincade A differentiation pathway for B1 cells in adult bone marrow PNAS, April 7, 2009; 106(14): 5773 - 5778. [Abstract] [Full Text] [PDF] L. S. de Paiva, A. Nobrega, G. O. De Melo, E. A. Hayashi, V. Carvalho, P. M. Rodrigues e Silva, M. Bellio, G. P. Teixeira, V. Rumjanek, S. S. Costa, et al. Selective blockade of lymphopoiesis induced by kalanchosine dimalate: inhibition of IL-7-dependent proliferation J. Leukoc. Biol., April 1, 2008; 83(4): 1038 - 1048. [Abstract] [Full Text] [PDF] A. Minami, I. Tsuboi, T. Harada, T. Fukumoto, M. Hiramoto, M. Koshinaga, Y. Hirabayashi, J. Kanno, T. Inoue, and S. Aizawa Inflammatory Biomarker, Neopterin, Suppresses B Lymphopoiesis for Possible Facilitation of Granulocyte Responses, Which Is Severely Altered in Age-Related Stromal-Cell-Impaired Mice, SCI/SAM Experimental Biology and Medicine, January 1, 2007; 232(1): 134 - 145. [Abstract] [Full Text] [PDF]

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