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Blood, 1 September 2005, Vol. 106, No. 5, pp. 1694-1702. Prepublished online as a Blood First Edition Paper on May 26, 2005; DOI 10.1182/blood-2005-02-0494. This Article Full Text (PDF) Supplemental Table and Figures All Versions of this Article: 2005-02-0494v1 106/5/1694    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chauveau, C. Articles by Anegon, I. Search for Related Content PubMed PubMed Citation Articles by Chauveau, C. Articles by Anegon, I. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 4, 2005 Accepted April 28, 2005 Heme oxygenase-1 expression inhibits dendritic cell maturation and pro-inflammatory function but conserves IL-10 expression Christine Chauveau, Severine Remy, Pierre J Royer, Marcelo Hill, Severine Tanguy-Royer, Francois X Hubert, Laurent Tesson, Regis Brion, Gaelle Beriou, Marc Gregoire, Regis Josien, Maria C Cuturi, and Ignacio Anegon* Institut National de la Sante et de la Recherche Medicale (INSERM) Unit 643 and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, France INSERM U601, Nantes, France * Corresponding author; email: ianegon{at}nantes.inserm.fr. Heme oxygenase-1 (HO-1) is an intracellular enzyme that degrades heme and inhibits immune responses and inflammation in vivo. In most cell types, HO-1 is inducible by inflammatory stimuli and oxidative stress. Here we demonstrate that human monocyte-derived immature DCs (iDCs) and several but not all freshly isolated rat splenic DC subsets and rat bone marrow-derived iDCs, spontaneously express HO-1. HO-1 expression drastically decreases during human and rat DC maturation induced in vitro. In human tissues, iDCs also express HO-1 whereas mature DCs do not. Induction of HO-1 expression with cobalt protoporphyrin (CoPP) in human and rat DCs inhibits LPS-induced phenotypic maturation and secretion of pro-inflammatory cytokines, resulting in the inhibition of alloreactive T cell proliferation. CoPP-treated DCs, however, retain the ability to produce the anti-inflammatory cytokine IL-10. Reactive oxygen species induced by LPS in DCs were inhibited by induction of HO-1. In conclusion, we identify for the first time, the capacity of HO-1 to block maturation of DCs and to inhibit pro-inflammatory and allogeneic immune responses while preserving IL-10 production. This novel immune function for HO-1 may be of interest for the inhibition of immune responses in autoimmune diseases, transplantation, and other conditions involving activation of the immune system. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Moreau, M. Hill, P. Thebault, J. Y. Deschamps, E. Chiffoleau, C. Chauveau, P. Moullier, I. Anegon, B. Alliot-Licht, and M. C. Cuturi Tolerogenic dendritic cells actively inhibit T cells through heme oxygenase-1 in rodents and in nonhuman primates FASEB J, September 1, 2009; 23(9): 3070 - 3077. [Abstract] [Full Text] [PDF] H. Matsushima, H. Tanaka, N. Mizumoto, and A. Takashima Identification of crassin acetate as a new immunosuppressant triggering heme oxygenase-1 expression in dendritic cells Blood, July 2, 2009; 114(1): 64 - 73. [Abstract] [Full Text] [PDF] S. Remy, P. Blancou, L. Tesson, V. Tardif, R. Brion, P. J. Royer, R. Motterlini, R. Foresti, M. 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