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Blood, 1 July 2005, Vol. 106, No. 1, pp. 372-375. Prepublished online as a Blood First Edition Paper on March 22, 2005; DOI 10.1182/blood-2005-02-0548. This Article Full Text (PDF) Supplemental Tables and Figures All Versions of this Article: 2005-02-0548v1 106/1/372    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Baldwin, C. Articles by Steinberg, M. H Search for Related Content PubMed PubMed Citation Articles by Baldwin, C. Articles by Steinberg, M. H Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 8, 2005 Accepted March 10, 2005 Association of Klotho, bone morphogenic protein 6 and annexin A2 polymorphisms with sickle cell osteonecrosis Clinton Baldwin*, Vikky G Nolan, Diego F Wyszynski, Qian-Li Ma, Paola Sebastiani, Stephen H Embury, Alice Bisbee, John Farrell, Lindsay Farrer, and Martin H Steinberg Center for Human Genetics, Department of Pediatrics, Boston University School of Medicine, Boston, MA, USA; Department of Medicine, Boston University School of Medicine, Boston, MA, USA Department of Medicine, Boston University School of Medicine, Boston, MA, USA Department of Medicine, Boston University School of Medicine, Boston, MA, USA; Boston University School of Public Health, Boston, MA, USA Boston University School of Public Health, Boston, MA, USA Department of Medicine, University of California at San Francisco and San Francisco General Hospital, San Franciso, CA, USA * Corresponding author; email: cbaldwin{at}bu.edu. In patients with sickle cell disease, clinical complications including osteonecrosis can vary in frequency and severity, presumably due to the effects of genes that modify the pathophysiology initiated by the sickle mutation. Here, we examined the association of single-nucleotide polymorphisms in candidate genes (cytokines, inflammation, oxidant stress, bone metabolism) with osteonecrosis in patients with sickle cell disease. Genotype distributions were compared between cases and controls using multiple logistic regression techniques. An initial screen and follow-up studies showed that individual SNPs and haplotypes comprised of several SNPs in bone morphogenetic protein 6, annexin 2, and klotho were associated with sickle cell osteonecrosis. These genes are important in bone morphology, metabolism and vascular disease. Our results may provide insight into the pathogenesis of osteonecrosis in sickle cell disease, help identify individuals who are at high risk for osteonecrosis, and thus allow earlier and more effective therapeutic intervention. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. A. Mont, L. C. Jones, and D. S. Hungerford Nontraumatic Osteonecrosis of the Femoral Head: Ten Years Later J. Bone Joint Surg. Am., May 1, 2006; 88(5): 1117 - 1132. [Abstract] [Full Text] [PDF] P. Sebastiani, C. T. Baldwin, V. Nolan, D. F. Wyszynski, Q.-L. Ma, J. Farrell, A. Bisbee, K. Waraska, L. A. Farrer, and M. H. Steinberg Polymorphisms (Snps) in Multiple Genes of the Tgf-{beta}/Bmp Pathway Are Associated with a Global Measure of Sickle Cell Disease Severity. Blood (ASH Annual Meeting Abstracts), November 16, 2005; 106(11): 74 - 74. [Abstract] V. G. Nolan, A. C. Rybicki, C. T. Baldwin, H. T. Cohen, A. H. Adewoye, D. F. Wyszynski, M. E. Fabry, R. L. Nagel, and M. H. Steinberg Creatinine Clearance in Sickle Cell Anemia Is Modulated by Genes in the TGF-{beta}/BMP Pathway. Blood (ASH Annual Meeting Abstracts), November 16, 2005; 106(11): 3175 - 3175. [Abstract]

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